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NOD.Cg-Ptgs2tm1Hahe H2b/PkamMmjax
Cat. No.: CEMM-07250581
NOD.B10 Cox-2flox Line C mice develop age-related Sjogren's syndrome xerostomia and sialadenitis, and are phenotypically indistinguishable from NOD.B10Sn-H2b/J mice. Cox-2 function may be deleted when Cre recombinase is introduced.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
H2b
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| Allele Name |
b variant
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| Gene Symbol |
H2
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| Gene Name |
histocompatibility-2
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| Chromosome |
17
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| MGI Accession ID | show more close |
| Strain of Origin |
Not Applicable
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| Molecular Note |
A targeting vector was designed to flank exons 4 and 5 with loxP sites. Deletion of these exons would cause a frame shift, resulting in a stop codon after eight missense amino acids in exon 6.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
NOD.B10Sn-H2b/J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together. The donating investigator reports mice can exhibit nervous behavior and may benefit from a quieter vivarium. They also report some (not all) breeders decline in fecundity after 1-2 litters, and replacing breeding units at 3-4 months of age may improve overall colony performance.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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