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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6(Cg)-Zfp503tm1.1Pnmn/J (Cat. No.: CEMM-07251020) | Inquiry | |
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Nolz1fl/fl mice have loxP sites flanking exon 3 of the zinc finger protein 503 (Zfp503) gene. These mice may be useful when studying dopaminergic axon guidance and innervation.
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| STOCK Sox11tm1.1Llei/J (Cat. No.: CEMM-07251021) | Inquiry | |
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Sox11f/f mice have loxP sites flanking the only coding exon of the SRY (sex determining region Y)-box 11 (Sox11) gene. These mice may be useful when studying embryonic and adult neurogenesis.
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| B6.Cg-Sntb1tm1.1Scf/J (Cat. No.: CEMM-07251023) | Inquiry | |
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Sntb1flox mice have loxP sites flanking exon 1 of the Sntb1 gene. These mice may be useful when studying the dystrophin complex and Duchenne muscular dystrophy.
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| B6;129-Gt(ROSA)26Sortm3Cos/J (Cat. No.: CEMM-07251045) | Inquiry | |
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Rosa26-H2BTom mice express a Cre-inducible H2B/RFP from the Gt(ROSA)26Sor locus. These mice are useful in studies where a red nuclear-localized Cre reporter is desired.Of note, these mice are also useful as a control line for other mouse strains including,, and all of which also contain a Cre-inducible full-length wildtype or mutant ret proto-oncogene (Ret) cDNA.
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| B6;SJL-Gt(ROSA)26Sorem1(TAg)Sac/J (Cat. No.: CEMM-07251057) | Inquiry | |
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Rosa26LSL-SV40-GFP mice have a CRISPR/cas9 generated insertion of a floxed STOP cassette and an SV40 T antigen coding region followed by an IRES-EGFP cassette inserted into the endogenous Gt(ROSA)26Sor locus. When crossed with a Cre recombinase expressing strain, removal of the floxed STOP cassette will result in SV40 and EGFP expression in cre expressing tissues. These mice may be useful for the generation of immortalized cell lines and fluorescent tracking of tumorigenesis.
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| FVB/NJ-Grid1em1Mpan/J (Cat. No.: CEMM-07251066) | Inquiry | |
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Grid1 floxed mice carry a CRISPR/Cas9 generated mutation resulting in loxP sites surrounding exon 4 of the (Grid1) gene. This strain may be useful for studying heightened aggression found in a subset of autism spectrum disorder (ASD) cases.
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| STOCK Gt(ROSA)26Sortm7(CAG-dTomato, -EGFP)Zjh/J (Cat. No.: CEMM-07251074) | Inquiry | |
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These IS2 reporter mice harbor a targeted mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette and an FRT-flanked dTomato (dimer Tomato) sequence preventing transcription of a CAG promoter-driven enhanced green fluorescent protein (EGFP). dTomato is expressed following cre-mediated recombination. EGFP is only expressed following cre-mediated and Flp-mediated recombination. This strain may be useful as an intersectional reporter for cre and FLP expression, or as a subtraction reporter for cre expression alone.
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| B6.Cg-Gt(ROSA)26Sortm8(CAG-HIST1H2BB/EGFP)Zjh/J (Cat. No.: CEMM-07251075) | Inquiry | |
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These LSL-h2b-GFP mice harbor a targeted mutation in the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven enhanced green fluorescent protein (EGFP). EGFP is only expressed following cre-mediated recombination. This strain may be useful as an intersectional reporter for cre expression.
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| STOCK Cckarem1(cre)Shah/J (Cat. No.: CEMM-07251083) | Inquiry | |
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CckarCre CRISPR-derived knock-in mice are designed to have 2A-Cre sequence inserted into the 3' UTR of the cholecystokinin A receptor (Cckar) gene. The endogenous Cckar promoter/enhancer regions direct expression of Cre recombinase to parts of the reproductive system, the central and peripheral nervous systems, and the gut, without disrupting endogenous gene expression. These mice are useful for studying mating behaviors, food intake, pancreatic exocrine secretion, gall bladder contractility and GI motility.
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| STOCK Ascl1tm2.1Fgu/JejoJ (Cat. No.: CEMM-07251086) | Inquiry | |
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Ascl1flox/flox mice have loxP sites flanking the entire coding region of the Ascl1 gene and also contain a Venus fluorescent sequence downstream of the floxed region. This mutant mouse strain may be useful in studying distinct neuronal cell populations, neuronal turnover, and neuronal migration. The donating investigator reports that the level of expression of the Venus reporter gene is below detection via direct fluorescence and immunohisotchemistry.
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For Research Use Only.