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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129S7-Itga3tm1Rdav/J (Cat. No.: CEMM-07250132) | Inquiry | |
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These f(α3) mutant mice harbor loxP sites flanking exons 11-18 of the Itga3 (integrin alpha 3 (or alpha3-integrin (α3-integrin)) gene and may be useful in generating conditional mutations for studying the role of Itga3 transmembrane cell adhesion receptors in neuronal functions in the developing and adult central nervous system, including synaptic plasticity and memory formation.
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| STOCK Gli3tm1Alj/J (Cat. No.: CEMM-07250139) | Inquiry | |
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These Gli3flox mutant mice harbor loxP sites flanking exon 8 of the GLI-Kruppel family member GLI3 (Gli3) gene and may be useful in generating conditional mutations for studying Hedgehog/Sonic Hedgehog signaling in the development of many organs (such as central nervous system and limb patterning), as well as the role of Gli3 in adult organs.
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| STOCK Bcl2tm1Irt/J (Cat. No.: CEMM-07250142) | Inquiry | |
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These Bcl2flox mutant mice harbor a loxP-flanked neo cassette upstream of exon 2, as well as a loxP site downstream of exon 2 of the Bcl2 (B-cell leukemia/lymphoma 2) gene and may be useful in generating conditional mutations for studying apoptosis, mitochondrial permeability, cell survival signaling, cancer, neurological disorders, and immunity.
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| B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ (Cat. No.: CEMM-07250143) | Inquiry | |
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These ROSA26-Syn-A53T mice allow cre-inducible expression of the familial Parkinson's disease-associated A53T missense mutant form of human alpha-synuclein (human A53T α-Syn or SYNA53T), and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.
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| B6;129-Gt(ROSA)26Sortm3(SNCA*E46K)Djmo/TmdJ (Cat. No.: CEMM-07250144) | Inquiry | |
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These ROSA26-Syn-E46K mice allow cre-inducible expression of the E46K missense mutant form of human alpha-synuclein (human E46K α-Syn or SYNE46K) associated with familial Parkinson's disease, dementia, and visual hallucinations, and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.
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| B6;129-Gt(ROSA)26Sortm2(SNCA*119)Djmo/TmdJ (Cat. No.: CEMM-07250146) | Inquiry | |
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These ROSA26-Syn119 mice allow cre-inducible expression of the Syn119 C-terminally truncated mutation of human alpha-synuclein (human α-Syn119 or SynCT119; associated with familial Parkinson's disease), and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.
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| STOCK Ednrbtm1Nrd/J (Cat. No.: CEMM-07250149) | Inquiry | |
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These Ednrbflex3 mutant mice harbor a loxP-flanked neo cassette upstream of exon 3, as well as a loxP site downstream of exon 3 of the Ednrb (endothelin receptor type B or ET-B receptor) gene and may be useful in generating conditional mutations for studying the role of Ednrb in development of melanocytes, development of neurons and glia of the enteric nervous system, neural crest-derived cells, mesenchymal-derived smooth muscle cells, vasodilation, mitogen signaling and cancer, and human Hirschsprung's disease (HSCR).
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| B6.129-Kcnn1tm1.2Jpad/J (Cat. No.: CEMM-07250172) | Inquiry | |
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The SK1-flox (delta neo) allele has loxP sites flanking the coding sequences of exons 3-5 (and an enhanced green fluorescent protein (EGFP) coding sequence just downstream of the second loxP site) in the Kcnn1 (also called SK1) locus. This allele is reported to have no EGFP expression and likely confers a null phenotype even before exposure to Cre recombinase. When bred to mice that express Cre recombinase, the SK1 sequences encoding the translation initiation site through transmembrane domain five are deleted in the cre-expressing tissues of the offspring. These SK1-flox (delta neo) mutant mice may be useful in studying the role of small-conductance calcium-activated potassium (SK) channels in after-hyperpolarization and action potentials in neurons, as well as synaptic plasticity and spatial and non-spatial memory.
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| B6.Cg-Col1a1tm1(CAG-Sirt1)Dsin/Mmjax (Cat. No.: CEMM-07250201) | Inquiry | |
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The SIRT1STOP (or SIRT1-Tg flox-STOP-flox) targeted allele has a floxed-STOP cassette and mouse sirtuin 1 (Sirt1) cDNA sequence inserted into the 3' UTR of the collagen A1 (Col1a1) locus. When bred to mice that express Cre recombinase, offspring will have the floxed-STOP cassette deleted in the cre-expressing tissue(s), resulting in Sirt1 overexpression in Col1a1-expressing cells. These SIRT1STOP (or SIRT1-Tg flox-STOP-flox) mice may be useful for generating conditional mutations for studying the role of sirtuin NAD+-deacetylases in aging, cancer, cellular stress resistance, genomic stability, IGF1 pathways, autoimmunity, inflammation, T cell tolerance, energy metabolism, neurodegeneration, insulin resistance, and diabetes.
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| STOCK Corttm1(cre)Zjh/J (Cat. No.: CEMM-07250206) | Inquiry | |
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Cst-T2A-Cre (Cort-T2A-Cre) mice have Cre recombinase expression directed to Cort-expressing cells (CST positive neurons) by the endogenous promoter/enhancer elements of the cortistatin locus.
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For Research Use Only.