B6.129-Kcnn1^tm1.2Jpad/J

The SK1-flox (delta neo) allele has loxP sites flanking the coding sequences of exons 3-5 (and an enhanced green fluorescent protein (EGFP) coding sequence just downstream of the second loxP site) in the Kcnn1 (also called SK1) locus. This allele is reported to have no EGFP expression and likely confers a null phenotype even before exposure to Cre recombinase. When bred to mice that express Cre recombinase, the SK1 sequences encoding the translation initiation site through transmembrane domain five are deleted in the cre-expressing tissues of the offspring. These SK1-flox (delta neo) mutant mice may be useful in studying the role of small-conductance calcium-activated potassium (SK) channels in after-hyperpolarization and action potentials in neurons, as well as synaptic plasticity and spatial and non-spatial memory.