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B6;129-Gt(ROSA)26Sortm1(SNCA*A53T)Djmo/TmdJ
Cat. No.: CEMM-07250143
These ROSA26-Syn-A53T mice allow cre-inducible expression of the familial Parkinson's disease-associated A53T missense mutant form of human alpha-synuclein (human A53T α-Syn or SYNA53T), and may be useful for studying the progressive dopaminergic neurodegeneration of Parkinson's disease and other synucleinopathies, Lewy bodies, and synaptic plasticity.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(SNCA*A53T)Djmo
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| Allele Name |
Targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
SNCA, synuclein alpha, human
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
A targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a human alpha-synuclein cDNA bearing a familial Parkinson's disease-linked A53T missense mutation (SYNA53T), and a bovine polyadenylation signal.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF1/J B6129SF2/J C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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