Online Inquiry
STOCK Gli3tm1Alj/J
Cat. No.: CEMM-07250139
These Gli3flox mutant mice harbor loxP sites flanking exon 8 of the GLI-Kruppel family member GLI3 (Gli3) gene and may be useful in generating conditional mutations for studying Hedgehog/Sonic Hedgehog signaling in the development of many organs (such as central nervous system and limb patterning), as well as the role of Gli3 in adult organs.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gli3tm1Alj
show more
close
|
| Allele Name |
targeted mutation 1
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
show more
close
|
| Gene Symbol |
Gli3
show more
close
|
| Gene Name |
GLI-Kruppel family member GLI3
show more
close
|
| Chromosome |
13
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
show more
close
|
| Molecular Note |
An FRT site flanked neomycin resistance gene cassette with a 5' loxP site was inserted upstream of exon 8 and an additional loxP site was inserted downstream of exon 8. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 8 floxed.
show more
close
|
| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
show more
close
|
For Research Use Only.
Related Products