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STOCK Ednrbtm1Nrd/J
Cat. No.: CEMM-07250149
These Ednrbflex3 mutant mice harbor a loxP-flanked neo cassette upstream of exon 3, as well as a loxP site downstream of exon 3 of the Ednrb (endothelin receptor type B or ET-B receptor) gene and may be useful in generating conditional mutations for studying the role of Ednrb in development of melanocytes, development of neurons and glia of the enteric nervous system, neural crest-derived cells, mesenchymal-derived smooth muscle cells, vasodilation, mitogen signaling and cancer, and human Hirschsprung's disease (HSCR).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Ednrbtm1Nrd
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Ednrb
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| Gene Name |
endothelin receptor type B
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| Chromosome |
14
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| Expressed Genes |
neo, neomycin resistance, bacterial
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A floxed neo cassette was placed upstream of exon 3 and an additional loxP site was inserted downstream of exon 3.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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