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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| C57BL/6-Ppp3r1tm1Stl/J (Cat. No.: CEMM-07250055) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exons 2-4 of the Ppp3r1 gene. This strain may be useful for generating conditional mutations in applications related to neural networks in learning and memory.
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| B6.129-Smn1tm1Jme/J (Cat. No.: CEMM-07250042) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking exon 7 of the Smn1 gene. This strain may be useful for generating conditional mutations in applications related to human spinal muscular atrophy (SMA) or other neuromuscular degenerative diseases.
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| STOCK Sim1tm1.2Az/J (Cat. No.: CEMM-07250063) | Inquiry | |
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These "Sim1-floxed exon 1" (2-loxP) mice may be useful in generating conditional mutations for studying basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) transcription factors, central nervous system development, early-onset/hyperphagic obesity, and regulation of appetite and energy balance.
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| B6;129P-Psen1tm1Vln/J (Cat. No.: CEMM-07250065) | Inquiry | |
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These PS1-floxed mice may be useful in generating conditional knockouts of Presenilin 1 for studying Alzheimer’s Disease.
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| B6;SJL-Tg(Thy1-cre/ERT2, -EYFP)VGfng/J (Cat. No.: CEMM-07250067) | Inquiry | |
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These transgenic mice (“SLICK” for single-neuron labeling with inducible Cre-mediated knock-out) have a tamoxifen inducible Cre-mediated recombination system and Enhanced Yellow Fluorescent Protein driven by 2 bidirectional copies of the mouse thymus cell antigen 1 promoter. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted neuron-specific deletions only in neurons that express Yellow Fluorescent Protein. The Donating Investigator reports that founder line V mice express the transgene sparsely in neurons of the central nervous system.
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| STOCK Esrrbtm1.1Nat/J (Cat. No.: CEMM-07250068) | Inquiry | |
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These Nr3b2CKO mutant mice may be useful in generating conditional mutations to study disorders of hearing and balance, inner ear development (such as endolymph-producing epithelia within the auditory and vestibular divisions), and control of cell fate decisions by nuclear receptors.
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| B6;CBA-Tg(Thy1-Brainbow1.0)LLich/J (Cat. No.: CEMM-07250079) | Inquiry | |
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These Brainbow transgenic mice allow labeling of individual neuronal types with approximately 166 distinguishable color variations in cre recombined cells, and may also be useful in conjunction with other Brainbow strains for neurobiological studies.
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| B6.Cg-Tg(Thy1-Brainbow2.1)RLich/J (Cat. No.: CEMM-07250086) | Inquiry | |
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These Brainbow 2.1 (founder line R) mice allow labeling of individual neurons in peripheral and central neurons with nuclear localized, membrane-targeted, or cytoplasmic fluorescent proteins in cre recombined cells, and may also be useful in conjunction with other Brainbow strains for neurobiological studies.
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| STOCK Gli2tm6Alj/J (Cat. No.: CEMM-07250089) | Inquiry | |
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These Gli2flox mutant mice harbor loxP sites flanking exons 7 and 8 of the GLI-Kruppel family member GLI2 (Gli2) gene and may be useful in generating conditional mutations for studying Hedgehog/Sonic Hedgehog signaling in the development of many organs (such as central nervous system and axis patterning), as well as the role of Gli2 in adult organs.
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| STOCK Gt(ROSA)26Sortm1(tTA)Roos/J (Cat. No.: CEMM-07250119) | Inquiry | |
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These ROSA:LNL:tTA mutant mice harbor a conditional mutation of the Gt(ROSA)26Sor locus with a loxP-flanked STOP cassette preventing transcription of the downstream optimized tetracycline-controlled transactivator protein. Applying both Cre-lox and Tet-Off technologies, these mutant mice may be useful for generating compound mutant mice in which expression of a tetracycline-responsive promoter element-driven gene of interest can be both directed to the cell types defined by the chosen Cre recombinase expression, as well as turned off by the addition of tetracycline (or its analog doxycycline).
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For Research Use Only.