Online Inquiry
STOCK Sim1tm1.2Az/J
Cat. No.: CEMM-07250063
These "Sim1-floxed exon 1" (2-loxP) mice may be useful in generating conditional mutations for studying basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) transcription factors, central nervous system development, early-onset/hyperphagic obesity, and regulation of appetite and energy balance.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Sim1tm1.2Az
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Sim1
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| Gene Name |
single-minded family bHLH transcription factor 1
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129X1/SvJ
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| Molecular Note |
A targeting vector was designed to place a loxP site just upstream of the ATG translational start site and a loxP-flanked PGK-Neo cassette downstream of the same exon of the targeted gene. The construct was injected into RW-4 ES cells. Chimeric mice were bred to C57BL/6 mice, and the neomycin selection cassette was excised from these mice by crossing to FVB transgenic mice with widespread Cre recombinase expression.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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