B6;SJL-Tg(Thy1-cre/ERT2, -EYFP)VGfng/J

These transgenic mice (“SLICK” for single-neuron labeling with inducible Cre-mediated knock-out) have a tamoxifen inducible Cre-mediated recombination system and Enhanced Yellow Fluorescent Protein driven by 2 bidirectional copies of the mouse thymus cell antigen 1 promoter. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted neuron-specific deletions only in neurons that express Yellow Fluorescent Protein. The Donating Investigator reports that founder line V mice express the transgene sparsely in neurons of the central nervous system.