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B6.129-Smn1tm1Jme/J
Cat. No.: CEMM-07250042
Common Name: SMNF7
These floxed mutant mice possess loxP sites flanking exon 7 of the Smn1 gene. This strain may be useful for generating conditional mutations in applications related to human spinal muscular atrophy (SMA) or other neuromuscular degenerative diseases.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Smn1tm1Jme
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Smn1
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| Gene Name |
survival motor neuron 1
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| Chromosome |
13
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
A floxed exon 7 and neomycin resistance cassette were introduced to the gene via homologous recombination. The floxed exon 7 and neo cassette do not appear to interfere with transcript splicing in mutant animals as determined by RT-PCR analysis.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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