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STOCK Gli2tm6Alj/J
Cat. No.: CEMM-07250089
These Gli2flox mutant mice harbor loxP sites flanking exons 7 and 8 of the GLI-Kruppel family member GLI2 (Gli2) gene and may be useful in generating conditional mutations for studying Hedgehog/Sonic Hedgehog signaling in the development of many organs (such as central nervous system and axis patterning), as well as the role of Gli2 in adult organs.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gli2tm6Alj
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| Allele Name |
targeted mutation 6
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Gli2
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| Gene Name |
GLI-Kruppel family member GLI2
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
Two loxP sites were inserted flanking exons 7 and 8, which are upstream of the exons encoding the zinc fingers. A neo cassette flanked with Frt sites was also inserted upstream of exon 7 and then removed with Flp DNA recombinase.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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For Research Use Only.
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