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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Gt(ROSA)26Sortm75.1(CAG-tdTomato*)Hze/J (Cat. No.: CEMM-07250555) | Inquiry | |
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Ai75(RCL-nT)-D (also called Ai75D or Ai75(RCL-nls tdT)-D) mice display nuclear-localized tdTomato fluorescence following Cre recombinase exposure.
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| B6;129-Tor1aem1Bcgen/WtdJ (Cat. No.: CEMM-07251089) | Inquiry | |
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CRISPR/Extreme Genome Editing technology was used to develop Tet(TorA) mice, which have a loxP-flanked STOP cassette followed by the tetracycline operator (tetO) inserted upstream of the start codon of the endogenous Tor1a gene. Expression of torsinA requires the Cre recombinase-mediated excision of the floxed STOP cassette. This mutant mouse strain may be useful for enabling spatiotemporal control of the endogenous torsinA allele and for studying its role in DYT1 dystonia pathogenesis and therapeutics.
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| B6.Cg-Calb1tm1.1(folA/cre)Hze/J (Cat. No.: CEMM-07250507) | Inquiry | |
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Calb1-2A-dgCre-D (or Calb1-T2A-dgCre-D) mice express a trimethoprim-inducible EGFP/Cre fusion gene directed by endogenous calbindin 1 promoter/enhancer elements. When induced, small-to-moderately increased Cre recombinase activity is directed at high levels to scattered cells of the cortex, hippocampus, cerebellum and striatum, and restricted cell populations in thalamus and hypothalamus.
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| B6.Cg-Pvalbtm1.1(cre/ERT2)Hze/J (Cat. No.: CEMM-07250438) | Inquiry | |
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Pvalb-T2A-CreERT2-D (Pvalb-2A-CreERT2-D) mice have Cre-ERT2 fusion gene expression directed to Pvalb-expressing cells by the endogenous promoter/enhancer elements of the parvalbumin locus. These mice are a Cre-lox tool that allows inducible Cre expression of genes in Pvalb-expressing cells/tissues.
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| B6.Cg-Nxph4tm1.1(cre/ERT2)Hze/J (Cat. No.: CEMM-07250481) | Inquiry | |
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These knock-in mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the neurexophilin 4 locus. When induced, cre activity is observed in cortical layer 6b neurons and other scattered small cells [possibly glia] throughout the cortex.
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| B6.Cg-Penktm1.1(cre/ERT2)Hze/J (Cat. No.: CEMM-07250482) | Inquiry | |
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These knock-in mice express a tamoxifen-inducible cre recombinase from the endogenous promoter/enhancer elements of the preproenkephalin locus. When induced, cre activity is observed in the striatum, olfactory tubercle, and sparse cells in the dentate gyrus and cortex.
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| B6.Cg-Pvalbtm5.1(cre/folA)Hze/J (Cat. No.: CEMM-07250483) | Inquiry | |
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Pvalb-T2A-dCre-D (Pvalb-2A-dCre-D) mice express a trimethoprim-inducible Cre recombinase directed to Pvalb-expressing cells by the endogenous promoter/enhancer elements of the parvalbumin locus. When induced, Cre recombinase activity is observed in scattered cells throughout the cortex, as well as restricted populations in the cerebellum, medulla, pons, pallidum, and thalamus.
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| B6;129S-Rasgrf2tm1(cre/folA)Hze/J (Cat. No.: CEMM-07250484) | Inquiry | |
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Rasgrf2-2A-dCre mice express a trimethoprim-inducible Cre recombinase directed by endogenous Rasgrf2 promoter/enhancer elements. When induced, Cre recombinase activity is observed in cortical layers 2/3 and other scattered cells of the cortex, hypothalamus, thalamus, and midbrain.
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| B6.Cg-Trib2tm1.1(cre/ERT2)Hze/J (Cat. No.: CEMM-07250485) | Inquiry | |
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Trib2-2A-CreERT2-D knock-in/knockout mice express an inducible CreERT2 fusion protein from the endogenous tribbles homolog 2 promoter/enhancer elements. When induced, cre activity is observed in superficial layer 5 cortical neurons, other scattered cells throughout the cortex, and brain vasculature. Disruption of the Trib2 gene is presumed.
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| B6.Cg-Fezf1tm1.1(cre/folA)Hze/J (Cat. No.: CEMM-07250557) | Inquiry | |
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Fezf1-2A-dCre-D mice express a trimethoprim-inducible Cre recombinase directed to Fezf1-expressing cells by the endogenous promoter/enhancer elements of the Fez family zinc finger 1 locus. When induced, small increases in Cre recombinase activity are observed in restricted populations within striatum and hypothalamus, as well as scattered positive cells in amygdala and cortex.
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For Research Use Only.