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B6;129-Tor1aem1Bcgen/WtdJ
Cat. No.: CEMM-07251089
Common Name: TetO(Tor1a)
CRISPR/Extreme Genome Editing technology was used to develop Tet(TorA) mice, which have a loxP-flanked STOP cassette followed by the tetracycline operator (tetO) inserted upstream of the start codon of the endogenous Tor1a gene. Expression of torsinA requires the Cre recombinase-mediated excision of the floxed STOP cassette. This mutant mouse strain may be useful for enabling spatiotemporal control of the endogenous torsinA allele and for studying its role in DYT1 dystonia pathogenesis and therapeutics.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tor1aem1Bcgen
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| Allele Name |
endonuclease-mediated mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inducible
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| Gene Symbol |
Tor1a
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| Gene Name |
torsin family 1
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6N
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| Molecular Note |
CRISPR-targeting inserted a floxed STOP cassette and tetracycline response element upstream of exon 1.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony or to C57BL/6J inbred mice. The donating investigator reports that homozygous Tet(TorA) mice are perinatal lethal, while heterozygotes are viable and fertile.
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For Research Use Only.
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