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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Tg(Colgalt2-cre)NF111Htz/J (Cat. No.: CEMM-07250842) | Inquiry | |
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These BAC transgenic mice express cre recombinase from the mouse Colgalt2 gene. Recombination has been observed in striatal-projecting pyramidal neurons of the isocortex and in pyramidal neurons in the piriform, subicular and lateral entorhinal cortices. This mouse line may be useful to investigators who want to study neuronal projections from the cerebral cortex to the striatum.
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| STOCK Tg(Cryaa-cre)10Mlr/J (Cat. No.: CEMM-07251012) | Inquiry | |
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MLR10 transgenic mice exhibit cre recombinase expression in both the lens epithelium and lens fibers under the transcriptional control of the mouse Cryaa (crystallin, alpha A) promoter modified by the insertion of a Pax6 consensus binding element/lens epithelial cell enhancer. Cre expression is not found in other parts of the eye.
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| B6.Cg-Gt(ROSA)26Sortm1(CAG-EGFP)Brsy/J (Cat. No.: CEMM-07250909) | Inquiry | |
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MITO-Tag mice conditionally express, in a Cre recombinase-dependent manner, a hemagglutinin (HA)-tagged EGFP (codon-optimized) that localizes to mitochondrial outer membranes. These features enable immunocapture of mitochondria from specific cell types without the need for cell sorting techniques.
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| C57BL/6-Tg(Csf1r-HBEGF/mCherry)1Mnz/J (Cat. No.: CEMM-07250522) | Inquiry | |
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These transgenic mice carry a BAC encoding a diphtheria toxin receptor-mCherry fusion protein (DTR-mCherry) preceded by a loxP-flanked transcriptional Stop element under the control of the Csf1r promoter. They are part of a two-gene approach to target monocytes and macrophages, but not conventional dendritic cells (cDCs).
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| D2.Cg-Tg(Plp1-cre/ERT)3Pop/SjJ (Cat. No.: CEMM-07250547) | Inquiry | |
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These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse Plp1, proteolipid protein (myelin) 1 promoter. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Tamoxifen administration allows for ablation of predetermined genes in oligodendrocytes and Schwann cells, and will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice.
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| STOCK Tg(Aldh1l1-EGFP, -DTA)D8Rth/J (Cat. No.: CEMM-07250586) | Inquiry | |
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In this transgenic strain, Aldh1l1 promoter-active cells in the brain and spinal cord (the majority being astrocytes) express EGFP. Cre-mediated excision of the floxed EGFP/Stop enables DTA-mediated ablation of these cells.
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| D2.Cg-Tg(Thy1-Brainbow1.1)MLich/SjJ (Cat. No.: CEMM-07250614) | Inquiry | |
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These Brainbow 1.1 (founder line M) mice allow mutually exclusive expression of three membrane-targeted fluorescent proteins in astrocytes (including glia) throughout the brain, providing unambiguous delineation of boundaries between adjacent astrocytes in cre recombined cells, and may also be useful in conjunction with other Brainbow strains for neurobiological studies.
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| B6.Cg-Tg(Camk2a-cre)3Szi/J (Cat. No.: CEMM-07250635) | Inquiry | |
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These R4Ag11 mice express nuclear-localized Cre recombinase from the mouse Camk2a promoter in the adult brain, with high levels in the forebrain.
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| 129S6.FVB(B6)-Tg(Drd1a-cre)AGsc/KndlJ (Cat. No.: CEMM-07250659) | Inquiry | |
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Cre is expressed from the mouse Drd1a promoter in this YAC transgenic strain (D1-Cre). The spatio-temporal pattern of Cre expression in dopaminoceptive neurons is reported to closely recapitulate that of the endogenous Drd1a gene in embryonic and adult stages.
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| C57BL/6J-Tg(Cdh3-cre/ERT2)NIDA158Htz/J (Cat. No.: CEMM-07250799) | Inquiry | |
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These transgenic BAC mice express tamoxifen-inducible cre-ERT2 from the mouse Cdh3 promoter. Expression occurs in Cdh3-expressing cells, including a subclass of inhibitory interneurons in the dorsal horn of the spinal cord.
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For Research Use Only.