STOCK Tg(Cryaa-cre)10Mlr/J

Cat. No.: CEMM-07251012

Common Name: CPV14/Cre; cry-cre; Mlr10; MLR10-Cre

MLR10 transgenic mice exhibit cre recombinase expression in both the lens epithelium and lens fibers under the transcriptional control of the mouse Cryaa (crystallin, alpha A) promoter modified by the insertion of a Pax6 consensus binding element/lens epithelial cell enhancer. Cre expression is not found in other parts of the eye.

Inquiry

Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Cryaa-cre)10Mlr show more close
Allele Name	transgene insertion 10 show more close
Allele Attributes	Recombinase-expressing show more close
Gene Symbol	Tg(Cryaa-cre)10Mlr show more close
Gene Name	transgene insertion 10 show more close
Chromosome	UN show more close
MGI Accession ID	3038243 show more close
Strain of Origin	FVB/N show more close
Molecular Note	The expression of sequence encoding Cre recombinase was driven by a modified alpha A crystallin promoter. The promoter consists of -282/+43 of the mouse Cryaa gene with an inserted copy of Pax6 consensus binding site in a 5' to 3' orientation at position -86 of the promoter. Seven lines were Created with this line having expression of the transgene in both the lens epithelium and lens fiber cells but not in other parts of the eye. show more close

HUSBANDRY
Suggested Controls	FVB/NJ show more close
Breeding Considerations	Hemizygotes and homozygotes are viable and fertile. show more close
Breeding Strategy	Noncarrier x Hemizygote; Hemizygote x Noncarrier show more close

For Research Use Only.