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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S-Gt(ROSA)26Sortm2(CAG-cre*)Yzwa/J (Cat. No.: CEMM-07250955) | Inquiry | |
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Rosa26PA-Cre B4 mice express a photoactivatable Cre recombinase (PA-Cre 3.0) following exposure to FLP recombinase. Specifically, FLP-mediated removal of the frt-flanked STOP cassette results in expression of the individual split Cre segments (nMag::CreN59 and pMag::CreC60). Subsequent illumination with blue-light causes nMag-pMag dimerization (Magnets-opti dimerization), which brings the split Cre segments together to form a functional Cre recombinase molecule. This allows for highly efficient DNA recombination in an internal organ of living mice through noninvasive external blue light illumination, without unintended leakiness in the dark condition.
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| STOCK HhatTg(TFAP2A-cre)1Will/J (Cat. No.: CEMM-07250497) | Inquiry | |
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These Creface transgenic mice have a cre-recombinase sequence driven by the human transcription factor AP-2, alpha promoter/enhancer elements, and a polyadenylation sequence followed by parts of exons 5-6 of Tfap2a, encoding the frontonasal prominence (FNP) and limb enhancer elements. This transgene integrated into intron 9 of the hedgehog acyltransferase (Hhat) gene, abolishing Hhat gene function. These mice may be useful for studying craniofacial development.
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| B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J (Cat. No.: CEMM-07250271) | Inquiry | |
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This knock-in mutation replaces the coding sequence of the (Atoh1) gene with a modified Cre-recombinase-progesterone receptor fusion protein (Cre-PR). The fusion gene activity is inducible by administration of RU486.
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| C57BL/6J-Gnetm1Dar/J (Cat. No.: CEMM-07251059) | Inquiry | |
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These mice possess a M743T mutation (initially designated as M712T) in the Gne gene. Additionally, the exon harboring the mutation (exon 12) is floxed. These mice may have applications in studies related to neuromuscular disorder hereditary inclusion body myopathy (HIBM).
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| B6.129S7-Pcdhgtm2Xzw/J (Cat. No.: CEMM-07250232) | Inquiry | |
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These Pcdh-γfcon3 mutant mice possess a loxP site upstream of constant exon 3 of gamma-protocadherin (Pcdh-γ) which was fused to EGFP, followed by a loxP-flanked PGK-neomycin resistance (neo) cassette. This strain may be useful for studying neuronal structure and function of hypothalamic neuronal circuitry.
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| STOCK Bap1tm2a(EUCOMM)Hmgu/BrugJ (Cat. No.: CEMM-07250876) | Inquiry | |
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Bap1lacZ mice express a β-galactosidase gene and are null for Bap1, in addition, exons 6-12 are flanked by loxP sites in this conditional knock-out-first strain. These mice may be useful in studies of clear cell renal carcinoma and von Hippel-Lindau syndrome.
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| B6.Cg-Gt(ROSA)26Sortm1(CAG-PA-GFP)Rmpl/J (Cat. No.: CEMM-07250435) | Inquiry | |
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These mice conditionally express nuclear enriched photoactivatable GFP (PA-GFP::NLS) and allow broad and strong fluorescent expression in most tissues of the body, and may be useful to rapidly mark and follow selected population of cells in the living animal.
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| B6;129S-Igs7tm85.1(tetO-gltI/GFP*)Hze/J (Cat. No.: CEMM-07250593) | Inquiry | |
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Ai85(TITL-iGluSnFr)-D (also called Ai85D) mice are a Cre/Tet-dependent, fluorescent glutamate indicator line, created by targeted insertion of floxed-STOP-iGluSnFr at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of iGluSnFr, an intensity-based glutamate-sensing fluorescent reporter that is fast and sensitive. Increased GFP fluorescence is observed following subsequent glutamate binding (such as excitatory synaptic activity).
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| B6;129S-Igs7tm79.1(tetO-hop/EGFP)Hze/J (Cat. No.: CEMM-07250506) | Inquiry | |
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Ai79(TITL-Jaws)-D (also called Ai79D) mice are a Cre/Tet-dependent, optogenetic line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). Following Cre-mediated removal of the STOP cassette, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of an improved Halorhodopsin/EGFP fusion protein (Halo57*K200R*W214F/EGFP or Jaws). Subsequent illumination of Jaws-expressing (EGFP fluorescent) cells with yellow-to-red light leads to reversible photoinhibition of action potential firing/neural activity in these cells.
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| B6.Cg-Igs7tm94.1(tetO-GCaMP6s)Hze/J (Cat. No.: CEMM-07250526) | Inquiry | |
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Ai94(TITL-GCaMP6s)-D (also called Ai94D) mice have a Cre/Tet-dependent, fluorescent calcium indicator GCaMP6s inserted into the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of GCaMP6 slow variant calcium indicator (GCaMP6s; an ultrasensitive detector of single neuronal action potentials with slower decay and response kinetics). Following subsequent calcium binding (such as neuronal activation), increased EGFP fluorescence is observed.
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For Research Use Only.