STOCK Bap1^{tm2a(EUCOMM)Hmgu}/BrugJ

Bap1^{tm2a(EUCOMM)Hmgu}

targeted mutation 2a

Conditional ready (e.g. floxed); Reporter; Null/Knockout

Bap1

Brca1 associated protein 1

14

4452731

LacZ is expressed in cells that normally express Bap1. Bap1 is expressed primarily in the kidney although there is some expression in stomach.

C57BL/6N-Atm1Brd

The L1L2_Bact_P cassette was inserted at position 30975706 of Chromosome 14 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 30978907. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be Created by flp recombinase expression in mice carrying this allele. Subsequent Cre expression results in a knockout mouse. If Cre expression occurs without flp expression, a reporter knockout mouse will be Created.

When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony or C57BL/6NJ inbred mice. The donating investigator indicates that homozygous mice are not viable.

Heterozygous x Noncarrier; Wild-type x Heterozygote