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B6.129S7-Pcdhgtm2Xzw/J
Cat. No.: CEMM-07250232
These Pcdh-γfcon3 mutant mice possess a loxP site upstream of constant exon 3 of gamma-protocadherin (Pcdh-γ) which was fused to EGFP, followed by a loxP-flanked PGK-neomycin resistance (neo) cassette. This strain may be useful for studying neuronal structure and function of hypothalamic neuronal circuitry.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pcdhgtm2Xzw
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Pcdhg
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| Gene Name |
protocadherin gamma cluster
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| Chromosome |
18
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| Expressed Genes |
GFP, Green Fluorescent Protein
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| MGI Accession ID | show more close |
| Site of Expression |
GFP is expressed in hypothalamic neurons.
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| Strain of Origin |
129S7/SvEvBrd-Hprtb-m2
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| Molecular Note |
The Pcdh-gamma targeting vector was designed to insert a loxP site upstream of constant exon 3 of gamma-protocadherin (Pcdh-gamma) which was fused to EGFP, followed by a loxP-flanked PGK-neomycin resistance (neo) cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF1/J C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony or C57BL/6J. The Donating Investigator states that fertility of homozygotes decreases quickly after 3 months of age.
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For Research Use Only.
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