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B6.129S-Atoh1tm5.1(Cre/PGR)Hzo/J
Cat. No.: CEMM-07250271
This knock-in mutation replaces the coding sequence of the (Atoh1) gene with a modified Cre-recombinase-progesterone receptor fusion protein (Cre-PR). The fusion gene activity is inducible by administration of RU486.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Atoh1tm5.1(cre/PGR)Hzo
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| Allele Name |
targeted mutation 5.1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Atoh1
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| Gene Name |
atonal bHLH transcription factor 1
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| Chromosome |
6
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
RU486-inducible Cre-mediated recombination will result in deletion of Math1 in the hindbrain, specifically in the conscious proprioceptive nuclei of the cortex at E10.5, and in most unconscious proprioceptive lineages in the cerebellum at E12.5-E14.5.
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| Strain of Origin |
129S7/SvEvBrd-Hprtb-m2
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| Molecular Note |
All coding sequence was replaced by a modified Cre/progesterone receptor fusion construct followed by an FRT flanked PGK-neomycin selection cassette. The selection cassette was subsequently excised by crossing to mice carrying Gt(ROSA)26Sortm1(FLP1)Dym. In the resulting mice, the inducible Cre is under the control of the endogenous gene promoter.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony or C57BL/6J inbred mice.
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For Research Use Only.
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