Online Inquiry
C57BL/6J-Gnetm1Dar/J
Cat. No.: CEMM-07251059
Common Name: GneM712T
These mice possess a M743T mutation (initially designated as M712T) in the Gne gene. Additionally, the exon harboring the mutation (exon 12) is floxed. These mice may have applications in studies related to neuromuscular disorder hereditary inclusion body myopathy (HIBM).
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gnetm1Dar
show more
close
|
| Allele Name |
targeted mutation 1
show more
close
|
| Allele Attributes |
Inserted expressed sequence; Humanized sequence
show more
close
|
| Gene Symbol |
Gne
show more
close
|
| Gene Name |
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
show more
close
|
| Chromosome |
4
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
show more
close
|
| Molecular Note |
A targeting vector was designed to insert the M743T (formerly described as M712T) substitution in exon 12. LoxP sites were inserted upstream of exon 12 and downstream of an FRT flanked PGK-neo in intron 12.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
show more
close
|
| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred to wildtype mice from the colony or C57BL/6J inbred mice. The donating investigator reports that homozygous mice do not live past P3. This lethal phenotype can be rescued by administrating sialic acid N-Acetylneuraminate (Neu5Ac) or its precursor N-Acetylmannosamine (ManNAc) to the dam.
show more
close
|
| Breeding Strategy |
Heterozygote x Wild-type
show more
close
|
For Research Use Only.
Related Products