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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| FVB(Cg)-Tg(Dhh-cre)1Mejr/J (Cat. No.: CEMM-07250252) | Inquiry | |
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The Dhh-cre transgene harbors a nuclear-localized Cre recombinase gene under control of the mouse desert hedgehog (Dhh) promoter/regulatory regions. These transgenic mice may be useful in generating cre-inducible mutations in Sertoli cell precursors (testes development/male germline), endothelial cells, and Schwann cells of the peripheral nervous system.
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| C57BL/6J-Taf1em2Ems/Mmjax (Cat. No.: CEMM-07251077) | Inquiry | |
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The conditional Taf1 floxed allele is a CRISPR/cas9 generated mutant that contains loxP sites flanking exon 8 (8-9) of the X-linked TATA-box binding protein associated factor 1 gene. These mice may be useful in generating conditional mutations to study X-linked dystonia-parkinsonism (XDP), intellectual disability, and autism spectrum disorder.
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| STOCK Fhl1tm1.1Mihi/J (Cat. No.: CEMM-07250904) | Inquiry | |
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The X-linked Fhl1pW122S allele has loxP sites flanking exons 5-6 and a W122S (tryptophan to serine) knock-in to exon 5 of the Fhl1 gene. Mutations in FHL1 are associated with multiple X-linked muscle diseases. Hemizygous males exhibit progressive late-onset muscle weakness.
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| B6.129T(SJL)-Foxg1tm1.1(cre)Ddmo/J (Cat. No.: CEMM-07250751) | Inquiry | |
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Foxg1-IRES-Cre knock-in mice contain a Cre recombinase sequence downstream of the Foxg1 promoter. These mice express FOXG1 in the telencephalon. In contrast to the Foxg1-Cre knock-in/knock-out strains, this Foxg1-IRES-Cre strain coexpresses FOXG1 and Cre recombinase, preventing Foxg1-haploinsufficiency and ectopic cre expression.
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| B6N.129-Mecp2tm1.1Vnar/J (Cat. No.: CEMM-07250307) | Inquiry | |
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Mecp2*A140V mice contain the amino acid mutation A140V in exon 4 of the endogenous methyl CpG binding protein 2 gene, and loxP sites flanking exons 3-4. These mice may be useful for studying impaired neurodevelopmental maturation associated with human RTT.
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| B6.Cg-Gt(ROSA)26Sortm2.1(CAG-EGFP, -DTA*G128D)Pjen/J (Cat. No.: CEMM-07250624) | Inquiry | |
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The RC::L-DTA allele has a cre-dependent FLEx switch containing an eGFP sequence and an inverted tox176 attenuated diphtheria toxin subunit alpha gene (DTA*G128D) that are uniquely flanked/separated by inward-facing lox sites (both lox2272 and loxP). Widespread eGFP fluorescence is observed in the absence of Cre recombinase. Subsequent exposure to Cre recombinase that places the DTA*G128D into the proper orientation for expression results in ablation of those cells.
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| STOCK Notch1tm4(cre)Rko/J (Cat. No.: CEMM-07250632) | Inquiry | |
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The high-activity Notch1 activation-dependent reporter knock-in allele, N1IP::CreHI, has the endogenous Notch1 intracellular domain (NICD1) replaced with a nuclear-localized Cre recombinase. Compared to N1IP::CreLO, this N1IP::CreHI allele has significantly improved sensitivity with five- to ten-fold increase in Cre activity. This improved sensitivity allows users to label cells experiencing moderate-to-lower Notch activation thresholds; including most cells/tissues known to utilize Notch1 during their development and/or maintenance.
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| STOCK Notch1tm5(cre/ERT2)Rko/J (Cat. No.: CEMM-07250633) | Inquiry | |
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The tamoxifen-inducible Notch1 activation-dependent reporter knock-in allele, N1IP::CreERT2, has the endogenous Notch1 intracellular domain (NICD1) replaced with a 6xMyc-tagged, tamoxifen-inducible Cre recombinase (6mtCreERT2). Similar to the N1IP::CreLO allele, this N1IP::CreERT2 allele is predominantly expressed in cells in which moderate-to-high levels of sustained Notch activity or repeated activation cycles are known to occur (e.g., endothelium), with the added benefit that Cre recombinase activity is tamoxifen-inducible.
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| B6;SJL-Slc6a3tm1.1(cre)Bkmn/J (Cat. No.: CEMM-07250045) | Inquiry | |
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These dopamine transporter IRES-cre (DATIREScre) mutant mice exhibit co-localization of Cre recombinase and endogenous Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3) gene expression and may be useful in neurobiological studies to facilitate the analysis of gene function in dopaminergic neurons, such as drug addiction or Parkinson's disease. This strain is discontinued. Please refer to B6.SJL-Slc6a3tm1.1(cre)Bkmn/J.
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| 129-Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/J (Cat. No.: CEMM-07250035) | Inquiry | |
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These knock-in mice were developed to utilize the mosaic analysis with double markers (MADM) system that allows simultaneous labeling and gene knockout in clones of somatic cells or isolated single cells in vivo. This strain carries the red fluorescent protein, Dsred2 (R) and the green fluorescent protein, EGFP (G) as markers to be used in conjunction with strains carrying the reciprocal chimeric marker genes (MADM-GR).
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For Research Use Only.