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C57BL/6J-Taf1em2Ems/Mmjax
Cat. No.: CEMM-07251077
The conditional Taf1 floxed allele is a CRISPR/cas9 generated mutant that contains loxP sites flanking exon 8 (8-9) of the X-linked TATA-box binding protein associated factor 1 gene. These mice may be useful in generating conditional mutations to study X-linked dystonia-parkinsonism (XDP), intellectual disability, and autism spectrum disorder.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Taf1em2Ems
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| Allele Name |
endonuclease-mediated mutation 2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Taf1
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| Gene Name |
TATA-box binding protein associated factor 1
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
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| Molecular Note |
CRISPR/Cas9 genome editing is used to insert loxP sites flanking exon 8 (with respect to transcripts Taf1-202 or -206) or exons 8-9 (with respect to transcript Taf1-201). Approximately 55 kb spanning the loxP sites was sequenced.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous (hemizygous) mice may be bred to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous females x hemizygote males maybe bred together. Taf1 is X-linked.
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| Breeding Strategy |
Heterozygote x Hemizygote
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For Research Use Only.
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