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B6;SJL-Slc6a3tm1.1(cre)Bkmn/J

Cat. No.: CEMM-07250045

These dopamine transporter IRES-cre (DATIREScre) mutant mice exhibit co-localization of Cre recombinase and endogenous Slc6a3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3) gene expression and may be useful in neurobiological studies to facilitate the analysis of gene function in dopaminergic neurons, such as drug addiction or Parkinson's disease. This strain is discontinued. Please refer to B6.SJL-Slc6a3tm1.1(cre)Bkmn/J.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Slc6a3tm1.1(cre)Bkmn
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Allele Name
targeted mutation 1.1
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Allele Attributes
Recombinase-expressing
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Gene Symbol
Slc6a3
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Gene Name
solute carrier family 6 (neurotransmitter transporter
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Chromosome
13
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Expressed Genes
Cre, Cre recombinase, bacteriophage P1
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MGI Accession ID
3689434
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Site of Expression
Cre recombinase activity is observed as early as embryonic day 15, and co-localizes with endogenous gene expression in adult dopaminergic cell groups (substantia nigra (SN) and ventral tegmental area (VTA), as well as in the retrorubral field). Lesser Cre recombinase activity occurs in adult olfactory bulb glomeruli, mimicking the known lower Slc6a3 (or DAT) expression in this tissue.
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Strain of Origin
Not Specified
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Molecular Note
An FRT flanked neo was removed from the locus, leaving Cre recombinase cDNA in the 3' UTR to allow bicistronic mRNA expression.
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HUSBANDRY
Suggested Controls
B6SJLF1/J
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Breeding Considerations
When maintaining a live colony, heterozygous mice are bred to wildtype siblings or to B6SJLF1/J F1 hybrids. Homozygous mutant mice are fertile.
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Breeding Strategy
+/+ sibling x Heterozygote
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For Research Use Only.
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