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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| C57BL/6N-Tg(Cnr1-EGFP/RNAi:Gad1)1Mirn/J (Cat. No.: CEMM-07250682) | Inquiry | |
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The Cnr1-eGFP-miGAD67 line 1 BAC transgenic mouse line is a hybrid reporter/miRNA knockdown model where cannabinoid receptor 1 interneuronal expression of a synthetic Gad1 miRNA precursor results in Gad1 transcript downregulation (silencing of GAD1 expression) via endogenous miRNA processing mechanisms. These mice may be useful in studying CNR1+ GABAergic interneurons in behavioral and molecular processes, as well as cell-type specific GABAergic disturbances in manifestations of schizophrenia.
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| C57BL/6N-Tg(Pvalb-tdTomato/RNAi:Gad1)3Mirn/J (Cat. No.: CEMM-07250683) | Inquiry | |
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The Pvalb-tdTomato-miGAD67 line 3 BAC transgenic mouse line is a hybrid reporter/miRNA knockdown model where parvalbumin interneuronal expression of a synthetic Gad1 miRNA precursor results in Gad1 transcript downregulation (silencing of GAD1 expression) via endogenous miRNA processing mechanisms. These mice may be useful in studying PVALB+ GABAergic interneurons in behavioral and molecular processes, as well as cell-type specific GABAergic disturbances in manifestations of schizophrenia.
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| B6;C3-Tg(A930038C07Rik-cre)4Aibs/J (Cat. No.: CEMM-07250175) | Inquiry | |
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These A930038C07Rik-Tg4-Cre mice express Cre recombinase under the control of the A930038C07Rik (RIKEN cDNA A930038C07 gene [also called epidermacan]) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, striatum, and cerebellum).
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| B6.Cg-Tg(A930038C07Rik-cre)1Aibs/J (Cat. No.: CEMM-07250336) | Inquiry | |
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These A930038C07Rik-Tg1-Cre mice express Cre recombinase under the control of the A930038C07Rik (RIKEN cDNA A930038C07 gene [also called epidermacan]) promoter/enhancer regions within the BAC transgene. These mice may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues; specifically in neocortical deep layer 5 (Layer 5B) cells/thick-tufted pyramidal neurons of adult mice.
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| STOCK Tg(Jam2-cre/ERT2)2Jrs/J (Cat. No.: CEMM-07250730) | Inquiry | |
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The JAM-B-CreER transgene has the junction adhesion molecule 2 promoter/enhancer regions directing tamoxifen-inducible Cre recombinase expression to OFF direction-selective retinal ganglion cells that respond to upward/dorsal motion (J-RGCs). These mice may be useful for tamoxifen-inducible recombination of lox-flanked (floxed) alleles in studying photoreceptors and retinal circuitry.
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| B6.Cg-Tg(Avil-icre/ERT2)AJwo/J (Cat. No.: CEMM-07250597) | Inquiry | |
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This strain has been discontinued. Please see the mixed genetic background version of this transgenic strain: Tg(Avil-icre/ERT2)AJwo/J.Advillin-CreERT2 transgenic mice (AvCreERT2) express a tamoxifen-inducible iCre recombinase directed by mouse Avil (advillin) promoter elements. When induced, iCre recombinase activity is observed in dorsal root ganglia and sensory neurons. These mice may have applications in the study of nociception.
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| 129S4.Cg-E2f1Tg(Wnt1-cre)2Sor/J (Cat. No.: CEMM-07250468) | Inquiry | |
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Wnt1-Cre2 transgenic mice express Cre recombinase under the control of the mouse Wnt1, wingless-related MMTV integration site 1, promoter and enhancer, and have applications in studies of cell lineage tracing in the developing neural crest and midbrain. See Detailed Description for information on germline expression.
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| B6.Cg-Tg(Thy1-EYFP)15Jrs/J (Cat. No.: CEMM-07250028) | Inquiry | |
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These Thy1-STOP-YFP mice possess loxP sites flanking the STOP codon between the promoter and EYFP gene. When bred to mice carrying cre recombinase EYFP will be expressed in motor neurons.
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| C57BL/6-Tg(Npas1-icre, -tdTomato)1Cschn/J (Cat. No.: CEMM-07250640) | Inquiry | |
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These Npas1-tdTom mice express icre and tdTomato in most (approximately 88%) of Npas1-expressing neurons in the brain. They are suitable for use in studies related to the external globus pallidus (GPe) nucleus in the basal ganglia.
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| STOCK Tg(Eno2-cre/ERT2)1Pohlk/J (Cat. No.: CEMM-07250479) | Inquiry | |
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Nse-CreERT2 transgenic mice express the tamoxifen inducible cre/ERT2 fusion gene in cerebellar lobular granule cells and in a few hippocampal dentate gyrus granule cells as directed by the rat Eno2 (enolase 2, gamma, neuronal) promoter. Cre-ERT2 fusion gene activity is inducible by the administration of tamoxifen.
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For Research Use Only.