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B6;C3-Tg(A930038C07Rik-cre)4Aibs/J
Cat. No.: CEMM-07250175
Common Name: A930038C07Rik-Tg4-Cre
These A930038C07Rik-Tg4-Cre mice express Cre recombinase under the control of the A930038C07Rik (RIKEN cDNA A930038C07 gene [also called epidermacan]) promoter/enhancer regions, and may be useful for generating conditional mutations for studying gain or loss of function and/or fate mapping in subgroups of brain tissues (including cortex, striatum, and cerebellum).
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(A930038C07Rik-cre)4Aibs
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| Allele Name |
transgene insertion 4
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Tg(A930038C07Rik-cre)4Aibs
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| Gene Name |
transgene insertion 4
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| Chromosome |
UN
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Hemizygous A930038C07Rik-Tg4-Cre mice are viable and fertile, with Cre expression directed to cortex, striatum, and cerebellum by the A930038C07Rik promoter/enhancer regions within the BAC transgene.
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| Strain of Origin |
(C57BL/6 x C3H)F1 x C57BL/6
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| Molecular Note |
The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-476E22, containing the entire A930038C07Rik locus (and other genes), was modified by targeting a Cre recombinase coding sequence (the CreERT2 sequence modified back to encode the normal Cre recombinase gene), SV40 polyA signal, and FRT flanked neomycin cassette to the ATG start site of the A930038C07Rik locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. The resulting modified BAC was microinjected into embryos from B6C3 mice ((C57BL/6 x C3H)F1 x C57BL/6). Founder line 4 was established.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6C3F1/J C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, hemizygous mice may be bred together, to wildtype (non-carrier) siblings, or to C57BL/6J inbred mice. The phenotype of homozygous mice has not yet been characterized.
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For Research Use Only.
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