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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129-Gt(ROSA)26Sortm2Nat/J (Cat. No.: CEMM-07250158) | Inquiry | |
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This strain carries an inverted human placental alkaline phosphatase (ALPP; PLAP) coding segment flanked by oppositely-oriented loxP sites integrated in the Gt(ROSA)26Sor gene. Cre excision of the floxed segment flips rather than excises the ALPP inversion and reinstates a transcriptionally active form of the gene. This reporter can be activated by tissue-specific cre recombinase in any cell in the body at any time in development. The result is very clear ALPP enzyme activity that can be detected histochemically.
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| B6;129-Rims2tm1.2Schc/J (Cat. No.: CEMM-07250071) | Inquiry | |
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When bred to Cre transgenic strains, the loxP-flanked exon 5 is deleted by Cre expression to produce a "RIM2alpha" isoform null allele. This strain may be helpful in the analysis of the function of alpha-RIMs in specific brain regions.
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| B6.129-Sncbtm1Sud/J (Cat. No.: CEMM-07250096) | Inquiry | |
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These mice possess loxP sites on either side of exon 2 of the targeted gene. Mice that are homozygous for this allele are viable, normal in size and do not display any gross physical or behavioral abnormalities, but breed very poorly. Protein levels are normal. When bred to a strain expressing Cre recombinase, this mutant mouse strain may be useful in studies of presynaptic proteins and synaptic vesicles.
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| STOCK Mnx1tm1Slp/J (Cat. No.: CEMM-07250207) | Inquiry | |
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These mice possess loxP sites on either side of exon3 of the Mnx1 (motor neuron and pancreas homeobox 1) gene. When bred to mice with a cre recombinase gene, exon 3 is deleted in cre-expressing tissues in the offspring.
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| B6.129S4-Grk5tm2Rjl/J (Cat. No.: CEMM-07250208) | Inquiry | |
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These mice carry a floxed allele of Grk5. When bred to mice with a cre recombinase gene, exons 7 and 8 of the targeted gene are deleted in the cre-expressing tissues in the offspring mice. This strain may be useful in mechanistic studies of muscarinic receptors and Alzheimer's disease.
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| STOCK Dnm1tm2.1Pdc/J (Cat. No.: CEMM-07250254) | Inquiry | |
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These mice possess loxP sites on either side of exons 2-4 of the Dnm1 (dynamin 1) gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. This strain may be useful in studies of endocytosis.
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| B6;129-Dlg1tm1Rlh/J (Cat. No.: CEMM-07250261) | Inquiry | |
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These mice possess loxP sites on either side of an exon encoding portions of both the PDZ1 and PDZ2 domains of the Dlg1 (discs, large homolog 1 (Drosophila); SAP97) gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. This strain may be useful for further characterizaton of the targeted gene's synaptic function.
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| B6.129S4(Cg)-Cdk5tm1.1Lht/J (Cat. No.: CEMM-07250287) | Inquiry | |
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These floxed Cdk5 (cyclin-dependent kinase 5) mice are useful for generating tissue-specific knockouts which may be useful in studies of synapse formation.
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| B6;129-Nrxn3tm3Sud/J (Cat. No.: CEMM-07250288) | Inquiry | |
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Exon 18 of these Nrxn3 (neurexin III) targeted mutant mice is flanked by loxP sites. This strain may be useful in generating tissue-specific alpha and beta isoform knock-outs for use in a variety of neurobiological studies.
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| STOCK Rims1tm3Sud/J (Cat. No.: CEMM-07250297) | Inquiry | |
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These Rims1 (regulating synaptic membrane exocytosis 1) floxed mice may be useful for generating animals lacking tissue-specific expression of the targeted gene.
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For Research Use Only.