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B6.129S4-Grk5tm2Rjl/J
Cat. No.: CEMM-07250208
These mice carry a floxed allele of Grk5. When bred to mice with a cre recombinase gene, exons 7 and 8 of the targeted gene are deleted in the cre-expressing tissues in the offspring mice. This strain may be useful in mechanistic studies of muscarinic receptors and Alzheimer's disease.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Grk5tm2Rjl
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| Allele Name |
targeted mutation 2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Grk5
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| Gene Name |
G protein-coupled receptor kinase 5
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| Chromosome |
19
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJaeSor
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| Molecular Note |
Exons 7 and 8 were flanked by loxP sites and a neomycin resistance cassette followed by a loxP site was placed in intron 8. Transient transfection with Cre recombinase excised the neomycin resistance cassette, leaving exons 7 and 8 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintained as a live colony, homozygotes or heterozygotes may be bred.
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For Research Use Only.
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