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B6;129-Dlg1tm1Rlh/J

Cat. No.: CEMM-07250261

These mice possess loxP sites on either side of an exon encoding portions of both the PDZ1 and PDZ2 domains of the Dlg1 (discs, large homolog 1 (Drosophila); SAP97) gene. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. This strain may be useful for further characterizaton of the targeted gene's synaptic function.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Dlg1tm1Rlh
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Allele Name
targeted mutation 1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Dlg1
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Gene Name
discs large MAGUK scaffold protein 1
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Chromosome
16
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MGI Accession ID
3817231
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Strain of Origin
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Molecular Note
A loxP site was inserted upstream of the exon encoding the carboxy terminus of the first PDZ domain and the amino terminus of the second PZD domain and an FRT flanked neo cassette with a 3' loxP site was inserted downstream of this exon. Germ line, flp mediated recombination was used to remove the neo cassette leaving the exon floxed.
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HUSBANDRY
Breeding Considerations
When maintained as a live colony, homozygotes or heterozygotes may be bred.
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For Research Use Only.
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