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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129-Fzd5tm2Nat/J (Cat. No.: CEMM-07250123) | Inquiry | |
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This is a conditional allele of the frizzled 5 gene in which the coding region was flanked by loxP sites and an alkaline phosphatase (AP) reporter was placed downstream. Cre-mediated recombination eliminates the coding region in a tissue-specific manner, ablates expression of the gene, and causes alkaline phosphatase (AP) to be expressed under the control of the frizzled 5 promoter. If recombination is mediated by an embryonic tissue-specific Cre, such as Sox2-Cre (e.g.), mice show a loss of cells in the parafasicular nucleus of the thalamus and defects in eye development.
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| B6.129S4-Gt(ROSA)26Sortm3(CAG-luc)Tyj/J (Cat. No.: CEMM-07250148) | Inquiry | |
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A loxP-flanked puromycin resistance/STOP cassette followed by a fusion of firefly luciferase and synthetic antigen peptide SIYRYYGL were introduced to the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus. After Cre activity, the recombined locus has high expression of Luciferase-SIY fusion protein. This mutant mouse strain may be useful in studies of immune response to a self-antigen or over-expressed tumor-associated antigen when used in combination with tumor-prone models.
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| B6;129-Pou4f1tm2.1Nat/J (Cat. No.: CEMM-07250181) | Inquiry | |
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These mice possess loxP sites on either side of the Pou4f1 (POU domain, class 4, transcription factor 1) coding region followed by an alkaline phosphatase (AP) reporter. When crossed with a cre recombinase-expressing strain, offspring express AP in the retina, several brain nuclei, dorsal root ganglia, trigeminal ganglion, and other cells/tissues.
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| B6.129-Pou4f2tm2.1Nat/J (Cat. No.: CEMM-07250182) | Inquiry | |
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These mice possess loxP sites on either side of the Pou4f2 (POU domain, class 4, transcription factor 2) coding region followed by an alkaline phosphatase reporter. When crossed with a cre recombinase-expressing strain, the offspring express AP in the retina, several brain nuclei, dorsal root ganglia, trigeminal ganglion, and other cells/tissues.
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| B6.129-Pou4f3tm1.1Nat/J (Cat. No.: CEMM-07250183) | Inquiry | |
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These mice possess loxP sites on either side of the Pou4f3 (POU domain, class 4, transcription factor 3) coding region followed by an alkaline phosphatase reporter. When crossed with a cre recombinase-expressing strain, the offspring express AP in the retina, dorsal root ganglia, and other cells/tissues.
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| B6;129-Casktm1Sud/J (Cat. No.: CEMM-07250048) | Inquiry | |
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These floxed mutant mice possess loxP sites flanking the first coding exon of the Cask gene. This strain may be useful for generating conditional mutations in applications related to synaptic function.
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| B6.129S7-Atoh1tm3Hzo/J (Cat. No.: CEMM-07250126) | Inquiry | |
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These mice possess loxP sites on either side of the coding region of the atonal homolog 1 gene (Atoh1). When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene and elucidating its role in cell fate commitment.
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| B6.129(Cg)-Dag1tm2.1Kcam/J (Cat. No.: CEMM-07250176) | Inquiry | |
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These mice possess loxP sites on either side of exon 2 of the Dag1 (dystroglycan 1) gene. When bred to mice with a cre recombinase gene under the control of a promoter of interest, exon 2 of the targeted gene is deleted in the tissue of interest.
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| STOCK Erc2tm1.2Sud/J (Cat. No.: CEMM-07250296) | Inquiry | |
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When crossed with a Cre recombinase-expressing strain, this floxed mutant strain is useful in eliminating tissue-specific expression of the Erc2 (ELKS/RAB6-interacting/CAST family member 2) gene.
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| B6;FVB-Tg(Crh-cre)1Kres/J (Cat. No.: CEMM-07250212) | Inquiry | |
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Cre recombinase in these mice is driven by the truncated mouse Crh promoter, and is expressed in neurons that express Crh.
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For Research Use Only.