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B6;129-Casktm1Sud/J
Cat. No.: CEMM-07250048
Common Name: CASK floxed
These floxed mutant mice possess loxP sites flanking the first coding exon of the Cask gene. This strain may be useful for generating conditional mutations in applications related to synaptic function.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Casktm1Sud
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Cask
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| Gene Name |
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
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| Chromosome |
X
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| Expressed Genes |
neo, neomycin resistance, bacterial
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The first coding exon of the Cask gene is flanked by loxP sites and a neomycin cassette is inserted into the intron adjacent to the floxed intron. The resulting allele is a hypermorph with Cask expression deCreased by ~66%.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintained as a live colony, heterozygous females are crossed with homozygous males or heterozygotes are intercrossed. Homozygous females are viable but fail to thrive.
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For Research Use Only.
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