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B6.129-Pou4f3tm1.1Nat/J
Cat. No.: CEMM-07250183
These mice possess loxP sites on either side of the Pou4f3 (POU domain, class 4, transcription factor 3) coding region followed by an alkaline phosphatase reporter. When crossed with a cre recombinase-expressing strain, the offspring express AP in the retina, dorsal root ganglia, and other cells/tissues.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pou4f3tm1.1Nat
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; No functional change
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| Gene Symbol |
Pou4f3
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| Gene Name |
POU domain
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| Chromosome |
18
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| Expressed Genes |
ALPP, alkaline phosphatase, placental, human
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
A loxP site was introduced to the 5' UTR (50 bp upstream of the ATG start codon), and three repeats of the SV40 early terminator were placed in the 3' UTR (300 bp downstream of the stop codon) along with a second loxP site, the human placental alkaline phosphatase (AP) gene, and an FRT flanked neomycin resistance gene. The targeting vector was introduced to 129-derived embryonic stem cells. The neomycin cassette was excised with a germline FLP recombinase.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintained as a live colony, heterozygotes or homozygotes may be bred.
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For Research Use Only.
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