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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Gt(ROSA)26Sortm1(rtTA, EGFP)Nagy/J (Cat. No.: CEMM-07250029) | Inquiry | |
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ROSA26-rtTA mice can be used to generate triple mutant mice in which the tissue specificity of a cre-transgenic line and doxycycline inducibility of the rtTA/TRE-controlled transgenes can be combined to regulate expression of a target gene.
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| B6N.129S6(Cg)-Gt(ROSA)26Sortm2(EGFP/cre)Alj/J (Cat. No.: CEMM-07250415) | Inquiry | |
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These R26MASTR mice express an eGFPcre fusion protein following FLP-mediated recombination, allowing simultaneous eGFP-labeling and cre-mediated deletion of floxed alleles within the same mutant cells.
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| B6N.129S6-Gt(ROSA)26Sortm1(CAG-tdTomato*, -EGFP*)Ees/J (Cat. No.: CEMM-07250509) | Inquiry | |
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ROSAnT-nG (also called nT/nG) is a nuclear-targeted, two-color fluorescent Cre reporter allele that express nuclear-localized red fluorescence in a widespread fashion prior to Cre recombinase exposure. Following exposure to Cre, nuclear-localized green fluorescence is observed. In addition to this C57BL/6NJ congenic background ROSAnT-nG strain, the ROSAnT-nG reporter allele is also available on a B6;129 mixed genetic background. The ROSAnT-nG reporter allele functions similarly to the mT/mG reporter allele (ROSAmT/mG), with nT/nG directed to nuclei and mT/mG directed to cell membrane.
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| B6N.Cg-Ccktm1.1(cre)Zjh/J (Cat. No.: CEMM-07250416) | Inquiry | |
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The Cck-IRES-Cre knock-in allele has an internal ribosome entry site and Cre recombinase in the 3' UTR of the cholecystokinin locus (Cck). As such, Cre recombinase expression is directed to Cck-expressing cells (cholecystokinin positive neurons) by the endogenous promoter/enhancer elements of the cholecystokinin locus.
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| B6N.Cg-Gad2tm2(cre)Zjh/J (Cat. No.: CEMM-07250417) | Inquiry | |
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Gad2-IRES-Cre knock-in mice have Cre recombinase expression directed to GAD2 positive neurons. These mice may be used to generate conditional mutations for studying GAD2 cell populations.
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| B6.129P2(Cg)-Gt(ROSA)26Sortm1(tTA)Roos/J (Cat. No.: CEMM-07250209) | Inquiry | |
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These ROSA:LNL:tTA mice can be used to generate compound mutant mice in which the tissue specificity of a cre-transgenic line and the tetracycline or dox responsiveness of the tTA/TRE-controlled transgenes can be combined to regulate expression of the target gene.
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| B6.129-Nlgn3tm4Sud/J (Cat. No.: CEMM-07250493) | Inquiry | |
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This strain constitutively expresses a mutant form of Nlgn3 (neuroligin 3; L399A, N400A, D402N, E297A, and K306A) fused to a cytoplasmic monomeric green fluorescent Venus tag. LoxP sites in the exon 2-exon 3 region enable the generation of conditional knockouts through cre-mediated excision.
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| C57BL/6J-Rab39bem6Lutzy/Mmjax (Cat. No.: CEMM-07250939) | Inquiry | |
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Rab39b cKO is a CRISPR/Cas9 generated mutant of the RAB39B, member RAS oncogene family gene with loxP sites flanking exon 2. Exposure to Cre recombinase deletes the floxed sequence and is expected to create a null allele. These mice may be useful in studying X-linked cognitive disability.
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| B6;129S6-Gt(ROSA)26Sortm1(CAG-cas9*/EP300*)Gers/J (Cat. No.: CEMM-07250940) | Inquiry | |
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This strain is currently unavailable due to replenishing of cryopreserved stocks. Interested customers who register interest will be contacted when the strain is again available Rosa26-LSL-dCas9-p300 knock-in mice (also called R26-LSL-dCas9p300 Core) have a loxP-flanked STOP cassette preventing expression of the dCas9p300 Core fusion protein - a codon-optimized, nuclease-deficient, catalytically dead Cas9 protein (dCas9) fused to the catalytic core of the human acetyltransferase p300. Following Cre recombinase and introduction of a single guide RNA (sgRNA), dCas9p300 Core binds to the target DNA sequence/locus, and that locus is subsequently activated by the p300 core domain. These mice allow Cre-inducible, RNA-guided transcriptional activation of target genes from promoters and both proximal and distal enhancers in a wide range of cellular processes.
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| B6.Cg-Spry1tm1.1Ssan Spry2tm1Ssan/J (Cat. No.: CEMM-07250934) | Inquiry | |
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Spry1/2flx mice harbor two floxed alleles - Spry1flx and Spry2flx. For each allele, removal of the floxed sequences deletes the protein-coding region - creating a null allele. These mice may be useful in studying T cell immunity (for example, negative regulation of T cell signaling via inhibition of Ras-MAPK signaling, or altering T cell metabolism for enhancing antitumor effects).
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For Research Use Only.