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C57BL/6J-Rab39bem6Lutzy/Mmjax
Cat. No.: CEMM-07250939
Rab39b cKO is a CRISPR/Cas9 generated mutant of the RAB39B, member RAS oncogene family gene with loxP sites flanking exon 2. Exposure to Cre recombinase deletes the floxed sequence and is expected to create a null allele. These mice may be useful in studying X-linked cognitive disability.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rab39bem6Lutzy
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| Allele Name |
endonuclease-mediated mutation 6
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Rab39b
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| Gene Name |
RAB39B
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
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| Molecular Note |
CRISPR/Cas9 genome editing used guide RNAs upstream (GTATTTACTAAAGGACTGTC and CTAAAGGACTGTCAGGAATC) and downstream (ATGAGCCTTCTTCCTAGGCC and CCTGTCAGAGATCCAGGCCT) to target exon 2. Donor DNAs were Created to insert loxP sites flanking exon 2.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Please note: this Rab39b is X-linked. Heterozygous females, hemizygous males and homozygous females are viable and fertile. When maintaining a live colony, homozygous females may be bred to hemizygous males.
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For Research Use Only.
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