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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6N.129S6(B6)-Chattm2(cre)Lowl/J (Cat. No.: CEMM-07250411) | Inquiry | |
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ChAT-IRES-Cre knock-in mice express Cre recombinase in cholinergic neurons, without disrupting endogenous Chat expression. These mice may be useful in neurobiological research of motor function, learning and memory, Alzheimer's disease, and Down syndrome, as well as obesity and diabetes research. our repository has two ChAT-IRES-Cre knock-in alleles from Dr. Bradford Lowell: ChAT-IRES-Cre::SV40pA::frt-neo-frt and ChAT-IRES-Cre::SV40pA::Δneo (Chattm1(cre)Lowl ;). Each allele also contains a partial neo fragment between the Cre and SV40 polyA. The donating investigator reports that the presence of the frt-flanked neo cassette may result in ectopic Cre expression, and they have never observed any ectopic expression in their ChAT-IRES-Cre::SV40pA::Δneo mice (January 2018).
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| C.129P2(B6)-Gt(ROSA)26Sortm1(tTA)Roos/J (Cat. No.: CEMM-07250120) | Inquiry | |
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These ROSA26-tTA mice can be used to generate compound mutant mice in which the tissue specificity of a cre-transgenic line and tetracycline (or doxycycline) inducibility of the tTA/TRE-controlled transgenes can be combined to regulate expression of the target gene.
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| CBy.B6-Gt(ROSA)26Sortm1(HBEGF)Awai/J (Cat. No.: CEMM-07250093) | Inquiry | |
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The Cre-inducible expression of DTR in these iDTR mutant mice render cells susceptible to ablation following Diphtheria toxin administration.
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| B6.Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/J (Cat. No.: CEMM-07250078) | Inquiry | |
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Ai9 is a Cre reporter tool strain designed to have a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. Ai9 mice express robust tdTomato fluorescence following Cre-mediated recombination. This strain is congenic on the C57BL/6J genetic background. The Ai9 allele is very similar in design to the Ai14 allele - differing only in the presence (Ai9) or absence (Ai14) of an att site-flanked neo selection cassette at the 3' end of the targeted allele. Importantly, both Ai9 and Ai14 may exhibit low levels of tdTomato expression prior to exposure to Cre recombinase - but the tdTomato expression levels after Cre recombination are greater than those baseline levels. As such, it is recommended that researchers include Cre-negative controls to establish the baseline tdTomato levels in their experiments. See Detailed Description for additional details.
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| B6.Cg-Tg(CAG-DsRed, -EGFP)5Gae/J (Cat. No.: CEMM-07250127) | Inquiry | |
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These IRG transgenic mice are a double-fluorescent, Cre-reporter strain; with widespread expression of red fluorescence prior to Cre recombinase exposure, and green fluorescence following cre-mediated recombination in a pattern determined by cre expression, and should provide a versatile tool for analyzing complex cellular relationships in a wide variety of tissues.
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| B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J (Cat. No.: CEMM-07250081) | Inquiry | |
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Ai14 is a Cre reporter tool strain designed to have a loxP-flanked STOP cassette preventing transcription of a CAG promoter-driven red fluorescent protein variant (tdTomato) - all inserted into the Gt(ROSA)26Sor locus. Ai14 mice express robust tdTomato fluorescence following Cre-mediated recombination. This strain is congenic on the C57BL/6J genetic background. The Ai14 allele is very similar in design to the Ai9 allele - differing only in the absence (Ai14) or presence (Ai9) of an att site-flanked neo selection cassette at the 3' end of the targeted allele. Importantly, both Ai14 and Ai9 may exhibit low levels of tdTomato expression prior to exposure to Cre recombinase - but the tdTomato expression levels after Cre recombination are greater than those baseline levels. As such, it is recommended that researchers include Cre-negative controls to establish the baseline tdTomato levels in their experiments. See Detailed Description for additional details.
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| B6.129-Gt(ROSA)26Sortm1Joe/J (Cat. No.: CEMM-07250122) | Inquiry | |
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Homozygous ROSA26 GNZ knock-in mice have widespread expression of a nuclear-localized green fluorescent protein/beta-galactosidase fusion protein (GFP-NLS-lacZ or GNZ) once an upstream loxP-flanked STOP sequence is removed. When bred to cre expressing mice, the resulting GNZ fusion protein expression in the offspring allows for enhanced (single cell level) visualization.
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| B6.FVB-Tg(CAG-EGFP, -ALPP)2.6Ggc/J (Cat. No.: CEMM-07250099) | Inquiry | |
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These piGAP transgenic reporter mice have expression of the eGFP-F-IRES-hPLAP dicistronic gene blocked by an unpstream loxP-flanked STOP-polyA sequence. When bred to mice that express Cre recombinase, the resulting offspring will have the STOP-polyA sequence deleted in the cre-expressing tissue(s), permitting dicistronic expression of human Placental Alkaline Phosphatase (PLAP or ALPP) and farnesylated Enhanced Green Fluorescent Protein (eGFP-F; optimized to target expression to the cytoplasmic side of the plasma membrane). These piGAP transgenic reporter mice allow Cre-inducible, eGFP-F and hPLAP expression in multiple cell and tissue types.
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| B6.129(Cg)-Gt(ROSA)26Sortm4(ACTB-tdTomato, -EGFP)Luo/J (Cat. No.: CEMM-07250069) | Inquiry | |
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mT/mG, with mT/mG directed to cell membrane and nT/nG directed to nuclei.
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| B6.Cg-Isl2tm1Arbr/J (Cat. No.: CEMM-07250091) | Inquiry | |
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These Isl2DTA mutant mice have the diphtheria toxin (DTA) gene inserted into the Isl2 (insulin related protein 2 (islet 2)) locus. Expression of DTA in Isl2-expressing cells is blocked by an upstream loxP-flanked STOP sequence. When bred to Cre recombinase-expressing mice, the STOP sequence is deleted in tissues where Cre is present, permitting DTA expression and subsequent cell ablation.
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For Research Use Only.