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B6.Cg-Isl2tm1Arbr/J
Cat. No.: CEMM-07250091
Common Name: Isl2DTA
These Isl2DTA mutant mice have the diphtheria toxin (DTA) gene inserted into the Isl2 (insulin related protein 2 (islet 2)) locus. Expression of DTA in Isl2-expressing cells is blocked by an upstream loxP-flanked STOP sequence. When bred to Cre recombinase-expressing mice, the STOP sequence is deleted in tissues where Cre is present, permitting DTA expression and subsequent cell ablation.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Isl2tm1Arbr
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Inserted expressed sequence
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| Gene Symbol |
Isl2
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| Gene Name |
insulin related protein 2 (islet 2)
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| Chromosome |
9
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| Expressed Genes |
Dta, Diphtheria toxin A chain
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| MGI Accession ID | show more close |
| Strain of Origin |
Not Specified
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| Molecular Note |
An IRES-loxP-stop-loxP-DTA (diphtheria toxin) cassette was inserted into the sequences encoding the 3'UTR of the gene.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mutant mice were bred to C57BL/6J mice to generate this congenic strain. When maintaining the live congenic colony, homozygous mice may be bred together.
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For Research Use Only.
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