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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S6-Bpnt1tm2Yrk/J (Cat. No.: CEMM-07250402) | Inquiry | |
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These floxed Bpnt1 mutant mice possess loxP sites flanking exons 4- 5 and are useful in generating tissue-specific conditional mutations.
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| B6.129S6(Cg)-Bpnt1tm2.1Yrk/J (Cat. No.: CEMM-07250403) | Inquiry | |
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These floxed Bpnt1 mutant mice possess loxP sites flanking exons 4- 5 and are useful in generating tissue-specific conditional mutations.
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| B6.129-Gbatm1Clk/J (Cat. No.: CEMM-07250445) | Inquiry | |
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Exons 9-11 of Gba (glucosidase, beta, acid) are flanked by loxP sites in this conditional model, useful in studies of Gaucher disease.
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| C57BL/6-Rab11fip5tm1Sud/J (Cat. No.: CEMM-07250457) | Inquiry | |
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In this conditional mutant strain, exon 2 of the Rab11fip5 (RAB11 family interacting protein 5 (class I)) gene is flanked by loxP sites.
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| B6.Cg-Zfp335tm1Caw/J (Cat. No.: CEMM-07250474) | Inquiry | |
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Zfp335 (zinc finger protein 335; also known as identified as a NRC-interacting factor 1 (Nif1)) is a regulator of vertebrate neurogenesis. This mutant in the human gene is associated with severe microcephaly, neuronal degeneration, and neonatal death. The promoter, exon 1 and exon 2 of the mouse gene, as well as an Frt-flanked neomycin cassette are flanked by loxP sites in this conditional targeted mutation strain, enabling tissue-specific knockouts mediated by Cre recombinase.
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| STOCK Fzd3tm2.1Nat/J (Cat. No.: CEMM-07250516) | Inquiry | |
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The largest coding exon of the Fzd3 (frizzled homolog 3 (Drosophila)) gene is flanked by loxP sites and tagged by hemagglutinin in this conditional mutant strain.
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| B6.129S6(SJL)-Prkcztm1.1Rlh/J (Cat. No.: CEMM-07250539) | Inquiry | |
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The catalytic domain of the mouse Prkcz gene is flanked by loxP sites in this conditional mutant strain. It enables the creation of Cre-mediated PKM-ζ isoform knockouts, useful in studies of synaptic plasticity, learning and memory.
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| STOCK Cacna1ctm3Hfm/J (Cat. No.: CEMM-07250548) | Inquiry | |
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Exons 14 and 15 of the mouse Cacna1c gene are flanked by loxP sites in this conditional knockout strain. L-type calcium channel dysregulation has been implicated in pathologies of the heart as well as skeletal muscle myopathies and neurodegenerative diseases.
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| STOCK Islr2tm2.1Ddg/J (Cat. No.: CEMM-07250569) | Inquiry | |
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A portion of exon 3 of the mouse Islr2 (Linx) gene is flanked by loxP sites in this targeted mutant strain. Cre excision of the floxed region results in a knockout of the gene.
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| B6.129(SJL)-Gnai2tm2.1Rneu/J (Cat. No.: CEMM-07250609) | Inquiry | |
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These mice conditionally express the G184S mutant form of Gnai2. Exons 5-9 of the gene are flanked by loxP sites and followed downstream by additional copy of exon 5 carrying the G184S mutation. Cre-mediated excision of floxed exons enables conditional expression of the mutant form of protein.
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For Research Use Only.