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B6.129(SJL)-Gnai2tm2.1Rneu/J

Cat. No.: CEMM-07250609

These mice conditionally express the G184S mutant form of Gnai2. Exons 5-9 of the gene are flanked by loxP sites and followed downstream by additional copy of exon 5 carrying the G184S mutation. Cre-mediated excision of floxed exons enables conditional expression of the mutant form of protein.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Gnai2tm2.1Rneu
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Allele Name
targeted mutation 2.1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Gnai2
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Gene Name
guanine nucleotide binding protein (G protein)
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Chromosome
9
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MGI Accession ID
5614236
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Strain of Origin
129/Sv
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Molecular Note
Exons 5-9 of the gene are flanked by loxP sites and followed downstream by an additional copy of exon 5 carrying a G184S mutation. An FRT flanked neomycin resistance cassette was placed 3'. FLP mediated recombination removed the FRT flanked neo cassette.
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HUSBANDRY
Suggested Controls
C57BL/6J Wild-type from the colony
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Breeding Considerations
Homozygous and heterozygous floxed mice are viable and fertile.
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Breeding Strategy
Heterozygote x Heterozygote
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For Research Use Only.
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