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STOCK Cacna1ctm3Hfm/J
Cat. No.: CEMM-07250548
Common Name: Cav1.2 loxP
Exons 14 and 15 of the mouse Cacna1c gene are flanked by loxP sites in this conditional knockout strain. L-type calcium channel dysregulation has been implicated in pathologies of the heart as well as skeletal muscle myopathies and neurodegenerative diseases.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Cacna1ctm3Hfm
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| Allele Name |
targeted mutation 3
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Cacna1c
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| Gene Name |
calcium channel
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
Exons 14 and 15 were left flanked by single loxP sites. This allele was generated using ES cells that were also used to generate Cacna1ctm2Hfm.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Homozygous and heterozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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