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B6.129-Gbatm1Clk/J
Cat. No.: CEMM-07250445
Common Name: FloxGBA
Exons 9-11 of Gba (glucosidase, beta, acid) are flanked by loxP sites in this conditional model, useful in studies of Gaucher disease.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gbatm1Clk
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Gba
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| Gene Name |
glucosidase
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| Chromosome |
3
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A targeting vector was designed to flank exons 9-11 with loxP sites. An FRT flanked neo was inserted as well as exons 8-4 of metaxin 1 in reverse orientation. The neo was removed by transient expression of FLP recombinase.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
Homozygous and heterozygous floxed mice are viable and fertile.
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For Research Use Only.
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