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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129P2(SJL)-Ntrk1tm1Ddg/J (Cat. No.: CEMM-07250470) | Inquiry | |
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These mice carry a hypomorphic floxed F592A mutation in mouse Ntrk1 (neurotrophic tyrosine kinase, receptor, type 1; also called TrkA). Signaling is effectively blocked by application of 1NMPP1. This strain is useful in studies of nerve growth and survival.
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| B6;129X1-Tyrc-2J Cdkn1atm2Hpw/J (Cat. No.: CEMM-07250500) | Inquiry | |
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This mouse strain features a Cre-inducible luciferase reporter gene inserted into exon 2 of the mouse Cdkn1a gene, knock-ing out expression. Cre-mediated excision of a floxed stop segment enables tissue-specific expression of luciferase under the direction of the endogenous Cdkn1a promoter.
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| B6;129-Gt(ROSA)26Sortm6(Fzd6)Nat/J (Cat. No.: CEMM-07250517) | Inquiry | |
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This knock-in line at the Gt(ROSA)26Sor (gene trap ROSA 26, Philippe Soriano) locus gives no expression of triple hemagglutinin (HA) epitope-tagged Fzd6 (frizzled homolog 6 (Drosophila)) in the absence of cre-mediated recombination. Following cre-mediated recombination, a loxP-stop-loxP cassette is excised and the downstream triple HA epitope-tagged Fzd6 coding region is expressed, driven by the Gt(ROSA)26Sor promoter.
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| B6;129S-Gt(ROSA)26Sortm2.1Ksvo/J (Cat. No.: CEMM-07250549) | Inquiry | |
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ReaChR protein (a red-shifted channelrhodopsin) was tagged with mCitrine fluorescent protein and placed under the conditional control of the Gt(ROSA)26Sor promoter. Excision of two stop cassettes (one flanked by loxP sites, another flanked by FRT sites) enables fluorescent expression. As an optogenetic tool, this strain is useful for the selective activation and mapping of neuron populations.Anecdotal reports suggest that the FRT-flanked Stop cassette may* be showing FRT-site read through in this line, effectively making this a cre-dependent strain only.
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| STOCK Megf8tm1.2Ddg/J (Cat. No.: CEMM-07250563) | Inquiry | |
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This strain carries a floxed allele of Megf8, identified as a novel modifier of BMP4 (bone morphogenetic protein 4) signaling in trigeminal ganglion (TG) neurons. Cre excision of the floxed region creates a knockout of the gene.
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| B6;129-Gt(ROSA)26Sortm7(CAG-tdTomato*)Nat/J (Cat. No.: CEMM-07250584) | Inquiry | |
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This reduced recombination, nuclear-localized tdTomato reporter strain (R26 mLSL-ntdT) enables extremely sparse cre-mediated labeling of cells and is appropriate for applications such as lineage tracing.
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| B6.Cg-Gt(ROSA)26Sortm2.2Ksvo/J (Cat. No.: CEMM-07250596) | Inquiry | |
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ReaChR protein (a red-shifted channelrhodopsin) was tagged with mCitrine fluorescent protein and placed under the conditional control of the Gt(ROSA)26Sor promoter. Excision of a single loxP- flanked stop cassette enables fluorescent expression. As an optogenetic tool, this strain is useful for the selective activation and mapping of neuron populations.
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| B6;129S6-Gt(ROSA)26Sortm1Acoh/J (Cat. No.: CEMM-07250690) | Inquiry | |
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Floxopatch (also called Optopatch) mice are a sensitive, fast optogenetic tool for targeted, simultaneous optical perturbation and measurement of membrane voltage. Animals express variants of a near-infrared archaerhodopsin-based voltage indicator (QuasAr2-dark mOrange2; QuasAr2 is near infrared fluorescent, dark mOrange2 is non-fluorescent) and a blue light-gated channelrhodopsin actuator (CheRiff-EGFP; green fluorescent) in the cell plasma membrane after cre-mediated excision of a floxed Stop cassette.
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| STOCK C1ql3tm1.1Sud/J (Cat. No.: CEMM-07250747) | Inquiry | |
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Exon 2 of the C1ql3 is flanked by loxP sites upstream of an mVenus fluorescent reporter in this conditional mutant strain. Cre-mediated excision of the floxed region results in a knockout allele and prevents mVenus expression.
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| B6;129S6-Igs7tm3(tetO-Optopatch3, CAG-tTA)Acoh/J (Cat. No.: CEMM-07250749) | Inquiry | |
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Ai155 Optopatch3 mice, an improved version of Optopatch2, are a sensitive, fast optogenetic tool for targeted, simultaneous optical perturbation and optical measurement of membrane voltage. Conditional expression is dependent on cre-mediated excision of a floxed Stop cassette.
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For Research Use Only.