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STOCK Megf8tm1.2Ddg/J
Cat. No.: CEMM-07250563
This strain carries a floxed allele of Megf8, identified as a novel modifier of BMP4 (bone morphogenetic protein 4) signaling in trigeminal ganglion (TG) neurons. Cre excision of the floxed region creates a knockout of the gene.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Megf8tm1.2Ddg
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Megf8
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| Gene Name |
multiple EGF-like-domains 8
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| Chromosome |
7
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
The final exon was flanked by a loxP site and an FRT flanked neomycin resistance cassette with a 3' loxP site. Flp-mediated recombination removed the selection cassette and left the last exon floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Homozygotes and heterozygotes are viable and fertile.
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For Research Use Only.
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