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B6;129S6-Igs7tm3(tetO-Optopatch3, CAG-tTA)Acoh/J
Cat. No.: CEMM-07250749
Common Name: Optopatch3 Ai155
Ai155 Optopatch3 mice, an improved version of Optopatch2, are a sensitive, fast optogenetic tool for targeted, simultaneous optical perturbation and optical measurement of membrane voltage. Conditional expression is dependent on cre-mediated excision of a floxed Stop cassette.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Igs7tm3(tetO-Optopatch3,CAG-tTA)Acoh
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| Allele Name |
targeted mutation 3
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inducible
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| Gene Symbol |
Igs7
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| Gene Name |
intergenic site 7
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| Chromosome |
9
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| Expressed Genes |
YFP, Yellow Fluorescent Protein, jellyfish
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| MGI Accession ID | show more close |
| Site of Expression |
Optopatch3 functionality is achieved in Cre expressing tissues after tetracycline-controlled transactivator (tTA) and Cre recombinase expression.
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| Strain of Origin |
(129S6/SvEvTac x C57BL/6NCrl)F1
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| Molecular Note |
The targeting construct contains a tetO (tetracycline response element; TRE)-loxP-Stop-loxP-Optopatch3-CAG-tTA (tetracycline-controlled transactivator). Optopatch3 is a bicistronic construct that coexpresses QuasAr3-mCitrine (an enhanced archaerhodopsin-3 (Arch)-based voltage indicator) and CheRiff (a sensitive blue-shifted optogenetic actuator)
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
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| Breeding Considerations |
Homozygotes and heterozygotes are viable and fertile.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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