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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S6-Gt(ROSA)26Sortm3Ksvo/J (Cat. No.: CEMM-07250941) | Inquiry | |
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Cre recombinase-mediated excision of a floxed neomycin cassette enables these R26-CAG-LNL-GtACR1-Fred-Kv2.1 mice to conditionally express GtACR1 (Guillardia theta anion channel rhodopsin 1) fused with Kv2.1 (Kcnb1, potassium voltage gated channel, Shab-related subfamily, member 1) soma trafficking domain and FusionRed fluorescent protein (Fred). This strain enables selective, conditional optogenetic hyperpolarization, silencing and labeling of neurons.
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| B6.Cg-Igs7tm174(tetO-EGFP/RNAi:Hdac1, CAG-tdTomato, -tTA2)Tasic/J (Cat. No.: CEMM-07250976) | Inquiry | |
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Ai174 (also called Ai174(TIT2L-EGFP-shHDAC1-ICL-tdT-tTA2)) is a Cre-dependent, Tet-controllable histone deacetylation tool strain with dual fluorescent reporters, created by targeted insertion at the Igs7 locus (TIGRE). Exposure to Cre recombinase removes both STOP cassettes, resulting in tTA2 expression, robust tdTomato fluorescence and EGFP/shHDAC1 fusion protein expression (robust EGFP fluorescence and potential knockdown of endogenous histone deacetylase 1 expression by short hairpin RNA shHDAC1). The EGFP/shHDAC1 expression may be expected to be diminished/eliminated by doxycycline.
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| B6.Cg-Gt(ROSA)26Sortm1(CAG-Eos*/Calm*)Mrc/J (Cat. No.: CEMM-07250982) | Inquiry | |
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R26-CAG-lsl-CaMPARI2 mice express CaMPARI2 fluorescent calcium reporter from a CAG promoter introduced to the Gt(ROSA)26Sor gene when a loxP-flanked STOP cassette is excised with Cre recombinase. CaMPARI changes from green to red fluorescence with high intracellular calcium and photoconversion light, and is thus useful in monitoring neuronal activity. A poster describing the strain can be found here.
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| STOCK Igs7tm86(tetO-CiVS/pHluorin)Hze/VpiJ (Cat. No.: CEMM-07250991) | Inquiry | |
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Ai86(TITL-ArcLight) mice are a Cre/Tet-dependent, voltage-sensitive, fluorescent line, created by targeted insertion at the Igs7 locus (TIGRE; an intergenic region on mouse chromosome 9 that allows reporter expression to be tightly regulated). After removal of the floxed-STOP cassette by Cre recombinase, they may be used to generate Tet-Off/Tet-On mutant animals with conditional (inducible/reversible) expression of the voltage-sensitive fluorescent protein ArcLight. ArcLight exhibits voltage-dependent FRET (Förster resonance energy transfer pairs) upon membrane depolarization, and enables optical recordings at high spatial resolution with intrinsic assignment of recorded signals to targeted cell populations.
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| STOCK Adgrl1tm2c(EUCOMM)Hmgu/SudJ (Cat. No.: CEMM-07251011) | Inquiry | |
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Exon 4 of the mouse Adgrl1 gene is flanked by loxP sites in this Lphn1 cKO strain. Cre recombinase-mediated excision of exon 4 generates and out-of-frame mutation. Loss of ADGRL1/LPHN1 protein has not been validated due to a lack of reliable antibody, but neurons from homozygous excised mice exhibit massive synaptic phenotypes.
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| STOCK Hic1tm1.1Tmun/J (Cat. No.: CEMM-07251070) | Inquiry | |
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Hic1f/f floxed mice have loxP sites flanking exon 2 of the Hic1 gene, which contains the translation initiation codon. These mice also contain a nuclear localized lacZ sequence downstream of the floxed region. This strain is useful for studying quiescent mesenchymal progenitor subpopulations and their role in tissue regeneration.
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For Research Use Only.