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STOCK Hic1tm1.1Tmun/J
Cat. No.: CEMM-07251070
Common Name: Hic1f
Hic1f/f floxed mice have loxP sites flanking exon 2 of the Hic1 gene, which contains the translation initiation codon. These mice also contain a nuclear localized lacZ sequence downstream of the floxed region. This strain is useful for studying quiescent mesenchymal progenitor subpopulations and their role in tissue regeneration.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Hic1tm1.1Tmun
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter
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| Gene Symbol |
Hic1
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| Gene Name |
hypermethylated in cancer 1
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
129Sv/Pas
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| Molecular Note |
A targeting vector contained LoxP sites flanking the major coding exon 2 of Hic1, a PGK-neo cassette flanked by FRT sites distal to exon 2 and upstream of the 3' LoxP site. An IRES-NLS-LacZ cassette distal to the 3' LoxP site (downstream of exon 2) was added to enable the efficient identification of Hic1 deleted cells. The male chimeras were bred with female Flippase-expressing mice for deletion of the PGK-neo cassette.
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For Research Use Only.
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