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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Nlgn3tm2Sud/J (Cat. No.: CEMM-07250299) | Inquiry | |
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This Nlgn3 (neuroligin 3) strain carries a hypomorphic mutation that reduces expression to approximately 10% that of wildtype levels in brain tissue.
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| STOCK Mir138-1tm1Mtm/Mmjax (Cat. No.: CEMM-07250323) | Inquiry | |
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These microRNA 138-1 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.
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| STOCK Mirc30tm1Mtm/Mmjax (Cat. No.: CEMM-07250341) | Inquiry | |
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These microRNA cluster 30 (miR15a/16-1) conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. This mutant mouse strain may be useful in studies of microRNA biology.
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| B6.129(Cg)-Nf1tm1Par/J (Cat. No.: CEMM-07250359) | Inquiry | |
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These mice possess loxP sites flanking exons 31-32 of the neurofibromatosis 1 (Nf1) gene and have applications in studies of cancer, neural crest development and neurofibromatosis type I.
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| B6;129P2-Gt(ROSA)26Sortm5Mom/MomJ (Cat. No.: CEMM-07250405) | Inquiry | |
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This allele can be cre-induced to generate stochastic expression of either Tau-tdTomato and a dominant negative GNAS or Tau-Turquoise in the cell type determined by the cre promoter.
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| B6;129P2-Gt(ROSA)26Sortm4Mom/MomJ (Cat. No.: CEMM-07250406) | Inquiry | |
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This allele can be cre-induced to generate stochastic expression of either Tau-Turquoise or Tau-tdTomato in the cell type determined by the cre promoter.
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| C57BL/6N-Gt(ROSA)26Sortm13(CAG-MYC, -CD2*)Rsky/J (Cat. No.: CEMM-07250427) | Inquiry | |
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In these R26StopFLMYC mice, Cre recombinase-mediated excision of a floxed STOP cassette allows expression of a CAG promoter driven human MYC (avian)) cDNA and truncated signaling deficient human CD2 (CD2 molecule) from the Gt(ROSA)26Sor locus. These mice may be useful in general studies of the role of MYC, including of its function in germinal center development, B cell proliferation and immune response.
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| STOCK Igs5tm1(ACTB-tdTomato, -EGFP)Luo/J (Cat. No.: CEMM-07250451) | Inquiry | |
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The MADM-7TG (Igs5TG) allele has the CMV enhancer/chicken beta-actin core promoter, the N-terminal portion of tdTomato, a beta-globin intronic sequence (containing frt and lox sites), and the C-terminal portion of mut4-EGFP all inserted into the Igs5 locus on chromosome 7 (~2.13 cM; ~0.7 kbp downstream of exon 5 of the Rps9 gene). These MADM-7TG mutants are designed for MADM (mosaic analysis with double markers), and must be crossed to MADM-7GT mice harboring a reciprocal mutation at the same locus. This MADM system allows Cre recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation, mitosis, and imprinting.
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| STOCK Mir325tm1Mtm/Mmjax (Cat. No.: CEMM-07250455) | Inquiry | |
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These microRNA 325 conditional mutant mice are designed to generate a null allele or a lacZ tagged null allele when combined with Flp or Cre recombinase expressing strains. lacZ expression is observed in the central nervous system, brain, spinal cord and visual sensory system.. This mutant mouse strain may be useful in studies of microRNA biology.
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| B6;129S-Gt(ROSA)26Sortm65.1(CAG-tdTomato)Hze/J (Cat. No.: CEMM-07250461) | Inquiry | |
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Ai65(RCFL-tdT)Δneo mice (also called Ai65(RCFL-tdT)-D, Ai65Δneo, or Ai65D) harbor the Rosa-CAG-FrtSTOPFrt-LoxSTOPLox-tdTomato::deltaNeo conditional allele designed with both an frt-flanked STOP cassette and a loxP-flanked STOP cassette preventing transcription of the tdTomato fluorescent protein. After removal of the flanked STOP cassettes by FLP- and Cre-recombination, tdTomato fluorescence is expected in cells/tissues expressing both FLP recombinase and Cre recombinase.
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For Research Use Only.