Online Inquiry
B6.129(Cg)-Nf1tm1Par/J
Cat. No.: CEMM-07250359
Common Name: Nf1flox
These mice possess loxP sites flanking exons 31-32 of the neurofibromatosis 1 (Nf1) gene and have applications in studies of cancer, neural crest development and neurofibromatosis type I.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Nf1tm1Par
show more
close
|
| Allele Name |
targeted mutation 1
show more
close
|
| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
show more
close
|
| Gene Symbol |
Nf1
show more
close
|
| Gene Name |
neurofibromin 1
show more
close
|
| Chromosome |
11
show more
close
|
| MGI Accession ID | show more close |
| Site of Expression |
When mice carrying this allele are mated to a Synapsin I promoter driven Cre transgenic mouse strain, NF1 function is abated in most differentiated neuronal populations, resulting in abnormal development of the cerebral cortex.
show more
close
|
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
show more
close
|
| Molecular Note |
A loxP-neomycin selection cassette was inserted into intron 30 and a single loxP site was inserted into intron 32.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
show more
close
|
For Research Use Only.
Related Products