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C57BL/6N-Gt(ROSA)26Sortm13(CAG-MYC, -CD2*)Rsky/J
Cat. No.: CEMM-07250427
In these R26StopFLMYC mice, Cre recombinase-mediated excision of a floxed STOP cassette allows expression of a CAG promoter driven human MYC (avian)) cDNA and truncated signaling deficient human CD2 (CD2 molecule) from the Gt(ROSA)26Sor locus. These mice may be useful in general studies of the role of MYC, including of its function in germinal center development, B cell proliferation and immune response.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm13(CAG-MYC,-CD2*)Rsky
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| Allele Name |
targeted mutation 13
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence; Humanized sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
CD2, CD2 molecule, human; MYC, MYC proto-oncogene, bHLH transcription factor, human
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6
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| Molecular Note |
A splice acceptor site, CAG promoter, floxed neo stop cassette human MYC cDNA, and an FRT flanked IRES sequence and human CD2 cDNA were knocked into intron 1 via homologous recombination. The human CD2 cDNA is a signaling-deficient truncated version.
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For Research Use Only.
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