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B6;129P2-Gt(ROSA)26Sortm5Mom/MomJ
Cat. No.: CEMM-07250405
Common Name: RoMo-dnGs
This allele can be cre-induced to generate stochastic expression of either Tau-tdTomato and a dominant negative GNAS or Tau-Turquoise in the cell type determined by the cre promoter.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm5Mom
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| Allele Name |
targeted mutation 5
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Dominant negative; No functional change
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| Expressed Genes |
CFP, Cyan Fluorescent Protein, jellyfish; RFP, Red Fluorescent Protein, coral
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| MGI Accession ID | show more close |
| Site of Expression |
When bred to mice that express Cre recombinase, the resulting offspring will have the STOP cassette deleted in the Cre-expressing tissue(s) resulting in stochastic expression of either Tau-tdTomato (RFP) and a dominant negative GNAS (guanine nucleotide binding protein, alpha stimulating) or Tau-Turquoise (CFP).
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| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
A construct was inserted between exons 1 and 2 of this locus that encodes the CAG promoter followed by a loxP flanked a B-geo-STOP cassette followed by a loxN site then a Tau-mTurquoise sequence and woodchuck hepatitis post-transcriptional regulatory element (WPRE) followed by a lox2272 then a loxN site followed by a Tau-tdTomato sequence immediately followed by an IRES and dominant negative Gnas sequence a WPRE and lox2272 site. This allele can be Cre-induced to generate stochastic expression of either Tau-Turquoise alone or Tau-tdTomato along with the dominant negative GNAS.
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For Research Use Only.
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