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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| C57BL/6-Per2tm3Jt/J (Cat. No.: CEMM-07251024) | Inquiry | |
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Color-Switch PER2::LUC reporter mice switch from click beetle red PER2 (period circadian clock 2)::LUCIFERASE protein expression to click beetle green PER2::LUCIFERASE expression upon cre recombination. This enables cell-type-specific circadian measurements.
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| B6.Cg-Adcyap1r1tm1.1(cre/GFP)Rpa/J (Cat. No.: CEMM-07251027) | Inquiry | |
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Adcyap1r1iCre:GFP knock-in mice should express iCre:GFP wherever Adcyap1r1 (adenylate cyclase activating polypeptide 1 receptor 1), a G protein-coupled receptor (GPCR), is normally expressed. Expression levels of the targeted gene have not been assessed, but no effect is anticipated as the insertion is beyond the termination codon.
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| B6.Cg-Avpr1atm1.1(cre/GFP)Rpa/J (Cat. No.: CEMM-07251028) | Inquiry | |
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Avpr1a1iCre:GFP knock-in mice should express iCre:GFP wherever Avpr1a (arginine vasopressin receptor 1A), a G protein-coupled receptor (GPCR), is normally expressed. Expression levels of the targeted gene have not been assessed, but no effect is anticipated as the insertion is beyond the termination codon.
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| C57BL/6J-Gt(ROSA)26Sortm1(CAG-Saa3, -EGFP)Litt/J (Cat. No.: CEMM-07251032) | Inquiry | |
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LoxP-STOP-loxP-SAA3 (also called LSL-SAA3) knock-in mice carry a conditional mutant allele in which Saa3 (serum amyloid A 3) and IRES-EGFP are over-expressed from a CAG promoter upon Cre recombinase-mediated excision of a loxP-flanked neomycin/Stop cassette. EGFP expression has not been assessed. This strain has been useful in studies of Th17 cell responses, inflammation, and autoimmunity.
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| B6;129S4-Plxnd1tm1.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07251051) | Inquiry | |
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Plexin1-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Plxnd1 (plexin D1) promoter in PLXND1-positive cortical glutamatergic pyramidal neurons (PyNs).
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| B6;129S4-Cux1tm1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07251052) | Inquiry | |
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Cux1-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Cux1 (cut-like homeobox 1) promoter in CUX1-positive cortical glutamatergic pyramidal neurons (PyNs).
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| B6;129S4-Eomestm1.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07251053) | Inquiry | |
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Tbr2-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Eomes (eomesodermin; also called Tbr2) promoter in EOMES-positive cortical glutamatergic pyramidal neurons (PyNs).
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| B6;129S4-Btg2tm1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07251054) | Inquiry | |
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Tis21-2A-CreER knock-in mice express tamoxifen-inducible CreERT2 fusion protein from the mouse Btg2 (BTG anti-proliferation factor 2; also called Tis21) promoter in BTG2-positive cortical glutamatergic pyramidal neurons (PyNs).
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| C57BL/6-Gcktm2885(icre)Thor/J (Cat. No.: CEMM-07251061) | Inquiry | |
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GckCre mice express improved Cre recombinase (icre) from the mouse Gck (glucokinase) promoter, enabling the excision of loxP-flanked sequences in GCK-positive regions of the brain (e.g. in neurons of the paraventricular thalamus (PVT)). This strain has been useful in Cre-dependent optogenetic and chemogenetic studies of glucose sensing and feeding behavior.
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| C57BL/6J-Slc6a2em1(cre)Lbrl/J (Cat. No.: CEMM-07251128) | Inquiry | |
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CRISPR-generated Slc6a2-p2a-Cre knock-in mice express cre recombinase from the mouse solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 (Slc6a2) promoter. This strain has been useful in studies of area postrema excitatory neurons as they relate to nausea-associated behaviors.
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For Research Use Only.